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NCT04630886
Use of Tranexamic Acid in Reduction of Post-Op Complications in Mohs Micrographic Surgery
EARLY_PHASE1 trial testing Tranexamic acid injection in Skin Neoplasms in 34 participants. Terminated before completion.
16 January 2024
Quick facts
| Lead sponsor | Riley McLean |
|---|---|
| Phase | EARLY_PHASE1 |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | supportive care |
| Enrollment | 34 |
| Start date | 16 June 2021 |
| Primary completion | 16 January 2024 |
| Estimated completion | 16 January 2024 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Tranexamic acid injection — full drug profile →
- Lidocaine Epinephrine
Conditions studied
- Skin Neoplasms — all drugs for Skin Neoplasms →
Sponsor
Riley McLean
Who can join
Adults 18 to 99, any sex, with Skin Neoplasms. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to evaluate the use of locally injected tranexamic acid (TXA) under the skin during Mohs micrographic surgery for removal of skin cancers in patients on anticoagulation. TXA may be helpful in reducing bleeding and pain during surgery, and may also lead to fewer post-operative complications following surgery such as graft loss, specifically in patients on blood-thinners.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Efficacy and Safety of Tranexamic Acid in Cancer Surgery. An Update of Clinical Findings and Ongoing Research.
Zec T, Di Napoli R, Fievez L, Ben Aziz M, et al · · 2022 · cited 6× · PMID 35818514 · DOI 10.2147/jmdh.s337250
Verify or expand the search:
- PubMed search for NCT04630886
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Tranexamic acid injection
Trials testing the same drug.
- NCT04387305 — Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study · Phase 3 · not yet recruiting
- NCT06604325 — Prophylactic Tranexamic Acid To Reduce Blood Loss During Caesarean Delivery. · NA · recruiting
- NCT06010368 — Comparing Intramyometrial Tranexamic Acid and Oxytocin for Blood Loss in Cesarean Section · Phase 3 · not yet recruiting
- NCT06509256 — Different Methods of Tranexamic Acid Application in Controlling Peri Operative Bleeding in Gynecomastia Surgery · EARLY_PHASE1 · not yet recruiting
- NCT06522984 — Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid · NA · recruiting
Other recruiting trials for Skin Neoplasms
Currently open trials in the same condition.
- NCT07415291 — CNN-Based AI Versus Physicians for Solitary Skin Lesion Diagnosis · active not recruiting
- NCT04267861 — M7824 Related Adverse Effects in Adults With Cancer · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04630886 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Riley McLean
- Last refreshed: 19 November 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04630886.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing