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NCT04628637
High GRP78 Levels in Covid-19 Infection: A Case-Control Study
trial testing Serum protein level analysis in Covid19 in 144 participants. Completed in 10 October 2020.
1 October 2020
Quick facts
| Lead sponsor | Kafkas University |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 144 |
| Start date | 16 April 2020 |
| Primary completion | 1 October 2020 |
| Estimated completion | 10 October 2020 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Serum protein level analysis
Conditions studied
- Covid19 — all drugs for Covid19 →
- Endoplasmic Reticulum Stress — all drugs for Endoplasmic Reticulum Stress →
Sponsor
Kafkas University
Who can join
18 and older, any sex, with Covid19 or Endoplasmic Reticulum Stress. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Covid-19 infection was declared a global pandemic by WHO on March 11, 2020. GRP78 protein is known to be involved in the intrusion of numerous viruses. Our current study tries to provide some insight into the variation of GRP78 protein levels in patients with Covid-19(-) pneumonia, Covid-19(+) pneumonia, and CT negative Covid-19 infection in comparison to the normal population through a larger number of cases. 42 patients who have Covid-19(-) pneumonia; 72 patients who have Covid-19 infection (30 pneumonia,42 CT negative patients) and 30 patient who have no known diseases (control group) will be included in the study after the clinical and radiological evaluation. Serum GRP78 levels of the subjects will be measured through a commercially available enzyme-linked immunosorbent assay (ELISA) kit.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Role of Serine Proteases and Host Cell Receptors Involved in Proteolytic Activation, Entry of SARS-CoV-2 and Its Current Therapeutic Options.
Dessie G, Dessie G, Malik T. · · 2021 · cited 14× · PMID 34079299 · DOI 10.2147/idr.s308176 -
Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy.
Wei S, Zhang N, Zhang H, Chen Z, et al · · 2026 · PMID 41986307 · DOI 10.1038/s41392-026-02600-z
Verify or expand the search:
- PubMed search for NCT04628637
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Kafkas University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04628637 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Kafkas University
- Last refreshed: 13 November 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04628637.
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