NCT04623320 (BRECLAIR) is a clinical trial of euglycaemic clamp test in Insulin Resistance, sponsored by University Hospital, Antwerp.

Who is sponsoring NCT04623320?

NCT04623320 is sponsored by University Hospital, Antwerp.

What drugs are being tested in NCT04623320?

Interventions in NCT04623320: euglycaemic clamp test, 13C glucose breath test.

What condition does NCT04623320 study?

NCT04623320 studies Insulin Resistance, Type 1 Diabetes.

Is NCT04623320 still recruiting?

NCT04623320 is currently status unknown. Last updated 18 March 2022.

Last reviewed 2022-03-18 · How we verify

NCT04623320: BRECLAIR

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Validation of a 13C Glucose Breath Test Compared With the Euglycaemic Clamp Test

Status unknown Last updated 18 March 2022

What this trial tests

trial testing euglycaemic clamp test in Insulin Resistance in 50 participants. Status unknown.

Timeline

27 October 2020

Primary endpoint
30 December 2022

31 March 2023

Quick facts

Lead sponsor	University Hospital, Antwerp
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	50
Start date	27 October 2020
Primary completion	30 December 2022
Estimated completion	31 March 2023
Sites	1 location across Belgium

Drugs / interventions tested

euglycaemic clamp test
13C glucose breath test

Conditions studied

Insulin Resistance — all drugs for Insulin Resistance →
Type 1 Diabetes — all drugs for Type 1 Diabetes →

Sponsor

University Hospital, Antwerp

Who can join

18 and older, any sex, with Insulin Resistance or Type 1 Diabetes. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Insulin resistance can be assessed by the euglycaemic clamp technique. To date, this is the golden standard, but it is not suited for clinical practice. A 13C glucose breath test will be tested as a valid alternative. The curve of the exhaled 13C CO2 as a function of glucose metabolism can be correlated to the curve of the glucose disposal rate obtained via the clamp technique.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The 13C Glucose Breath Test Accurately Identifies Insulin Resistance in People With Type 1 Diabetes.
Mertens J, Roosens L, Braspenning R, Vandebeeck J, et al · · 2025 · cited 9× · PMID 38487831 · DOI 10.1210/clinem/dgae175
Insulin Resistance and CGM-Derived Parameters in People With Type 1 Diabetes: Are They Associated?
Clinck I, Mertens J, Wouters K, Dirinck E, et al · · 2024 · cited 7× · PMID 38198792 · DOI 10.1210/clinem/dgae015

Verify or expand the search:

Other recruiting trials for Insulin Resistance

Currently open trials in the same condition.

NCT07403604 — Effect of Insulin Lowering on Lipogenesis · Phase 1 · recruiting
NCT07226128 — The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV · NA · recruiting
NCT07505745 — MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity · Phase 2 · recruiting
NCT07220694 — Effects of Sabroxy® Supplementation on Insulin Resistance and Cognitive Function in Adults With Mild Cognitive Impairmen · NA · recruiting
NCT06768827 — New Mechanisms of Obesity · NA · recruiting

Other University Hospital, Antwerp trials

Trials by the same sponsor.

NCT07455422 — A Study of Barrett's Esophagus Patients: Optimization of a Risk Model to Better Predict the Development of Cancer Recurr · NA · not yet recruiting
NCT07020715 — A Phase IIa Study of Vitamin D3 Tolerogenic Dendritic Cells (tolDC) for Multiple Sclerosis · Phase 2 · not yet recruiting
NCT07443761 — Patients Undergoing Pancreatic Surgery at the Antwerp University Hospital. · active not recruiting
NCT06372847 — DISE-HNS Effect Study · NA · recruiting
NCT07189091 — CReep and Maintenance flUid Sodium Chloride ADministration rEduction in cRitically Ill adultS · Phase 4 · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04623320 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Antwerp
Last refreshed: 18 March 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04623320.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing