NCT04622618 is a EARLY_PHASE1 clinical trial of Gabapentin in Nausea, Postoperative, sponsored by Ain Shams University.

Who is sponsoring NCT04622618?

NCT04622618 is sponsored by Ain Shams University.

What drugs are being tested in NCT04622618?

Interventions in NCT04622618: Gabapentin.

What condition does NCT04622618 study?

NCT04622618 studies Nausea, Postoperative, Vomiting, Postoperative, Pain, Postoperative.

Is NCT04622618 still recruiting?

NCT04622618 is currently completed. Last updated 27 May 2021.

Last reviewed 2021-05-27 · How we verify

NCT04622618

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Optimal Dosing of Preoperative Gabapentin for Prevention of Postoperative Nausea and Vomiting

Completed EARLY_PHASE1 Last updated 27 May 2021

What this trial tests

EARLY_PHASE1 trial testing Gabapentin in Nausea, Postoperative in 150 participants. Completed in 15 February 2021.

Timeline

15 September 2020

Primary endpoint
20 January 2021

15 February 2021

Quick facts

Lead sponsor	Ain Shams University
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	150
Start date	15 September 2020
Primary completion	20 January 2021
Estimated completion	15 February 2021
Sites	2 locations across Egypt

Drugs / interventions tested

Gabapentin (Gabapentin) — full drug profile →

Conditions studied

Nausea, Postoperative — all drugs for Nausea, Postoperative →
Vomiting, Postoperative — all drugs for Vomiting, Postoperative →
Pain, Postoperative — all drugs for Pain, Postoperative →

Sponsor

Ain Shams University

Who can join

Adults 18 to 64, any sex, with Nausea, Postoperative or Vomiting, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Overall incidence of postoperative nausea and vomiting (PONV) after general anesthesia is 40-90 % . gabapentin has been incorporated into "fast-track" packages and improved recovery during surgery protocols to avoid unintended side effects associated with opioid alternatives. Interestingly, gabapentin has also been noted to reduce the effects of chemotherapy-induced nausea, effective in treatment of gravidarum hyperemesis, and postdural puncture emesis. Different dosing regimens were tested.The goal of the study is to determine the most effective dose of oral gabapentin given 1 hour prior to surgery on the occurrence and severity of PONV and drug side effects in the first 24 hours postoperatively to find the most effective dose of gabapentin with the least side effects.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Gabapentin

Trials testing the same drug.

NCT07047040 — Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin · Phase 2, PHASE3 · not yet recruiting
NCT07131527 — Comparison Between Oral Gabapentin Versus Diclofenac Sodium in Post-operative Analgesia Laparoscopic Cholecystectomy · NA · recruiting
NCT04613024 — Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty · EARLY_PHASE1 · withdrawn
NCT07389551 — Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic · NA · completed
NCT06992427 — High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Che · Phase 3 · recruiting

Other recruiting trials for Nausea, Postoperative

Currently open trials in the same condition.

NCT07066306 — Effects of Local Ketamine in Orthognathic Procedures · NA · active not recruiting
NCT03645239 — Post-operative Emesis and Pain Outcomes After Cesarean Delivery · active not recruiting

Other Ain Shams University trials

Trials by the same sponsor.

NCT07435493 — Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstru · NA · not yet recruiting
NCT07482540 — Role of Dexmedatomidine Drug in Prevention of Atrial Fibrillations Post Mitral Valve Surgery · NA · not yet recruiting
NCT07531030 — Posterior Pericapsular Deep Gluteal Block Combined With Pericapsular Nerve Group and Lateral Femoral Cutaneous Nerve Blo · NA · not yet recruiting
NCT06839027 — Arterial to Central co2gap in Relation to Outcome After Cardiopulmonary Bypass · not yet recruiting
NCT07516535 — DISS vs FANS in Suction-Assisted RIRS for Medium-Sized Renal Stones · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04622618 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ain Shams University
Last refreshed: 27 May 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04622618.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing