NCT04621799 is a Phase 2, PHASE3 clinical trial of Fibrin sealant in Low Back Pain, sponsored by Pauza, Kevin, MD.

Who is sponsoring NCT04621799?

NCT04621799 is sponsored by Pauza, Kevin, MD.

What drugs are being tested in NCT04621799?

Interventions in NCT04621799: Fibrin sealant.

What condition does NCT04621799 study?

NCT04621799 studies Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy, Annular Disc Tear.

Is NCT04621799 still recruiting?

NCT04621799 is currently status unknown. Last updated 9 November 2020.

Last reviewed 2020-11-09 · How we verify

NCT04621799

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Fibrin for Chronic Multi-level Discogenic Low Back Pain

Status unknown Phase 2, PHASE3 Last updated 9 November 2020

What this trial tests

Phase 2, PHASE3 trial testing Fibrin sealant in Low Back Pain in 400 participants. Status unknown.

Timeline

11 June 2018

Primary endpoint
31 December 2020

30 June 2021

Quick facts

Lead sponsor	Pauza, Kevin, MD
Phase	Phase 2, PHASE3
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	400
Start date	11 June 2018
Primary completion	31 December 2020
Estimated completion	30 June 2021
Sites	1 location across United States

Drugs / interventions tested

Fibrin sealant — full drug profile →

Conditions studied

Low Back Pain — all drugs for Low Back Pain →
Disc Disease — all drugs for Disc Disease →
Disc Degeneration — all drugs for Disc Degeneration →
Radiculopathy — all drugs for Radiculopathy →

Sponsor

Pauza, Kevin, MD

Who can join

Adults 18 to 80, any sex, with Low Back Pain or Disc Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Intra-annular injections of non-autologous fibrin for moderate to severe chronic low back pain (LBP).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Development, Pathogenesis, and Regeneration of the Intervertebral Disc: Current and Future Insights Spanning Traditional to Omics Methods.
Hickman TT, Rathan-Kumar S, Peck SH. · · 2022 · cited 40× · PMID 35359439 · DOI 10.3389/fcell.2022.841831

Verify or expand the search:

Other recruiting trials for Low Back Pain

Currently open trials in the same condition.

NCT07526012 — Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome · NA · recruiting
NCT07535047 — Placebo-Induced Hypoalgesia During Transcutaneous Electrical Nerve Stimulation Application in Low Back Pain · NA · recruiting
NCT07463729 — Evaluation of Stabilization Training With Biofeedback in Lumbosacral Spine Pain Syndrome · NA · recruiting
NCT07250568 — Office Program Effects on Pain, Posture, Muscle Physiology, Stress, Ergonomics, and Quality of Life in LBP Workers · NA · recruiting
NCT07467070 — Effectiveness of Pilates on Postural Correction, Core Strength and Flexibility in Younger Individuals With Non-specific · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04621799 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Pauza, Kevin, MD
Last refreshed: 9 November 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04621799.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing