NCT04620070: ON-SCENE

ON-SCENE Initiation of Extracorporeal CardioPulmonary Resuscitation During Refractory Out-of-Hospital Cardiac Arrest

Completed NA Last updated 24 December 2025

What this trial tests

NA trial testing ECPR in Extracorporeal Membrane Oxygenation in 221 participants. Completed in 1 July 2025.

Timeline

15 October 2021

Primary endpoint
1 July 2025

1 July 2025

Quick facts

Lead sponsor	Erasmus Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	crossover
Masking	none
Primary purpose	treatment
Enrollment	221
Start date	15 October 2021
Primary completion	1 July 2025
Estimated completion	1 July 2025
Sites	4 locations across Netherlands

Drugs / interventions tested

• ECPR

Conditions studied

• Extracorporeal Membrane Oxygenation — all drugs for Extracorporeal Membrane Oxygenation →
• Cardiac Arrest — all drugs for Cardiac Arrest →

Sponsor

Erasmus Medical Center

Who can join

Adults 18 to 50, any sex, with Extracorporeal Membrane Oxygenation or Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Hypothesis: Implantation of on-scene ECPR by the HEMS teams in patients with sustained out-of-hospital cardiac arrest, results in the rapid return of circulation and, thus, improved survival and less neurological impairment, which is associated with lower health care costs.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Improving access to extracorporeal membrane oxygenation for out of hospital cardiac arrest: pre-hospital ECPR and alternate delivery strategies.
   Song C, Dennis M, Burns B, Dyson S, et al · · 2022 · cited 27× · PMID 36566221 · DOI 10.1186/s13049-022-01064-8
2. ECMO in Cardiac Arrest: A Narrative Review of the Literature.
   De Charrière A, Assouline B, Scheen M, Mentha N, et al · · 2021 · cited 26× · PMID 33540537 · DOI 10.3390/jcm10030534
3. A national multi centre pre-hospital ECPR stepped wedge study; design and rationale of the ON-SCENE study.
   Ali S, Moors X, van Schuppen H, Mommers L, et al · · 2024 · cited 22× · PMID 38632661 · DOI 10.1186/s13049-024-01198-x
4. Extracorporeal membrane oxygenation for critically ill adults.
   Burrell A, Kim J, Alliegro P, Romero L, et al · · 2023 · cited 18× · PMID 37750499 · DOI 10.1002/14651858.cd010381.pub3
5. Selection of patients for mechanical circulatory support for refractory out-of-hospital cardiac arrest.
   Linde L, Mørk SR, Gregers E, Andreasen JB, et al · · 2023 · cited 10× · PMID 36371665 · DOI 10.1136/heartjnl-2022-321405
6. Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review.
   Raasveld SJ, Volleman C, Combes A, Broman LM, et al · · 2022 · cited 9× · PMID 36424482 · DOI 10.1186/s40635-022-00478-z
7. Extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest - current status.
   Suverein MM, Maessen JG, van de Poll MCG. · · 2023 · cited 8× · PMID 37865873 · DOI 10.1097/mcc.0000000000001102
8. Extracorporeal Membrane Oxygenation in Infarct-Related Cardiogenic Shock.
   Freund A, Desch S, Pöss J, Sulimov D, et al · · 2022 · cited 6× · PMID 35268347 · DOI 10.3390/jcm11051256