Who is sponsoring NCT04615754?

NCT04615754 is sponsored by University of Aarhus.

What drugs are being tested in NCT04615754?

Interventions in NCT04615754: Hyperketonemia - use of ketone (3-OHB) infusion, Placebo - use of saline infusion.

What condition does NCT04615754 study?

NCT04615754 studies Pulmonary Hypertension, Ketonemia.

Is NCT04615754 still recruiting?

NCT04615754 is currently completed. Last updated 2 December 2021.

Last reviewed 2021-12-02 · How we verify

NCT04615754: KEPAH

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ketones for Pulmonary Hypertension - Effects on Hemodynamics

Completed Phase 2 Last updated 2 December 2021

What this trial tests

Phase 2 trial testing Hyperketonemia - use of ketone (3-OHB) infusion in Pulmonary Hypertension in 20 participants. Completed in 29 November 2021.

Timeline

18 August 2020

Primary endpoint
1 May 2021

29 November 2021

Quick facts

Lead sponsor	University of Aarhus
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	20
Start date	18 August 2020
Primary completion	1 May 2021
Estimated completion	29 November 2021
Sites	1 location across Denmark

Drugs / interventions tested

Hyperketonemia - use of ketone (3-OHB) infusion
Placebo - use of saline infusion

Conditions studied

Pulmonary Hypertension — all drugs for Pulmonary Hypertension →
Ketonemia — all drugs for Ketonemia →

Sponsor

University of Aarhus

Who can join

18 and older, any sex, with Pulmonary Hypertension or Ketonemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In the present study, patients with idiopathic pulmonary hypertension (IPAH) and chronic thromboembolic pulmonary hypertenion will be investigated in a randomized cross-over design with ketone infusions and placebo. Invasive and non-invasive hemodynamics will be evaluated

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Hemodynamic Effects of Ketone Bodies in Patients With Pulmonary Hypertension.
Nielsen R, Christensen KH, Gopalasingam N, Berg-Hansen K, et al · · 2023 · cited 31× · PMID 37183871 · DOI 10.1161/jaha.122.028232
Exogenous Ketones in Cardiovascular Disease and Diabetes: From Bench to Bedside.
Kansakar U, Nieves Garcia C, Santulli G, Gambardella J, et al · · 2024 · cited 4× · PMID 39685849 · DOI 10.3390/jcm13237391
Ketones in Cardiovascular Health and Disease: An Updated Review.
Shrestha S, Harrison I, Dosunmu A, Song P. · · 2026 · PMID 41597225 · DOI 10.3390/cells15020150

Verify or expand the search:

Other recruiting trials for Pulmonary Hypertension

Currently open trials in the same condition.

NCT07179380 — Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension · Phase 3 · recruiting
NCT07073820 — A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have P · Phase 2 · recruiting
NCT06351345 — 129 Xenon Imaging in Patients Treated With Sotatercept · Phase 2 · recruiting
NCT07187206 — Safety and Efficacy of FETO in CDH Phase III · Phase 3 · recruiting
NCT07206173 — Londrina Activities of Daily Living Protocol in Pulmonary Hypertension · recruiting

Other University of Aarhus trials

Trials by the same sponsor.

NCT07209540 — European LUpuS Inception-Cohort Developing initiATivE · not yet recruiting
NCT07317401 — Investigating the Effects of Intermittent Hypoxia-Hyperoxia Treatment (IHHT) in People With Post-Viral Myalgic Encephalo · NA · not yet recruiting
NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
NCT07528339 — Prospective RegIstry for Oncologic Reirradiation (PRIOR-DK) · not yet recruiting
NCT07451028 — Effect of an Oral Neuromuscular Training Device on Dysphagia · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04615754 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Aarhus
Last refreshed: 2 December 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04615754.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing