NCT04610645 (ROOCT) is a clinical trial of OCT in Head and Neck Cancer, sponsored by Krankenhaus Barmherzige Schwestern Linz.

Who is sponsoring NCT04610645?

NCT04610645 is sponsored by Krankenhaus Barmherzige Schwestern Linz.

What drugs are being tested in NCT04610645?

Interventions in NCT04610645: OCT, Dermatoscope.

What condition does NCT04610645 study?

NCT04610645 studies Head and Neck Cancer, Radiotherapy.

Is NCT04610645 still recruiting?

NCT04610645 is currently completed. Last updated 3 March 2026.

Last reviewed 2026-03-03 · How we verify

NCT04610645: ROOCT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer

Completed Last updated 3 March 2026

What this trial tests

trial testing OCT in Head and Neck Cancer in 30 participants. Completed in 8 April 2025.

Timeline

8 June 2020

Primary endpoint
8 December 2024

8 April 2025

Quick facts

Lead sponsor	Krankenhaus Barmherzige Schwestern Linz
Status	Completed
Study type	OBSERVATIONAL
Enrollment	30
Start date	8 June 2020
Primary completion	8 December 2024
Estimated completion	8 April 2025
Sites	1 location across Austria

Drugs / interventions tested

OCT
Dermatoscope

Conditions studied

Head and Neck Cancer — all drugs for Head and Neck Cancer →
Radiotherapy — all drugs for Radiotherapy →

Sponsor

Krankenhaus Barmherzige Schwestern Linz — full company profile →

Who can join

Adults 18 to 99, any sex, with Head and Neck Cancer or Radiotherapy. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT). Another key question is whether subclinical OCT detected skin damage correlates with acute and late clinical toxicity.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Radiation-induced alterations in multi-layered, in-vitro skin models detected by optical coherence tomography and histological methods.
Bromberger L, Heise B, Felbermayer K, Leiss-Holzinger E, et al · · 2023 · cited 4× · PMID 36862637 · DOI 10.1371/journal.pone.0281662
Monitoring of Early Skin Reactions by Optical Coherence Tomography and Dermatoscopy in Patients Receiving Radiation Therapy for Head and Neck Cancer.
Heise B, Schlagnitweit P, Pollak R, Felbermayer K, et al · · 2025 · cited 1× · PMID 40548163 · DOI 10.1016/j.adro.2025.101793

Verify or expand the search:

Other trials of OCT

Trials testing the same drug.

NCT07149740 — Data Gathering for A10900 · recruiting
NCT05135312 — Etanercept Therapy for Nails Psoriasis Monitoring With Noninvasive Imaging · Phase 4 · unknown
NCT06442176 — Choroid In Coronary Artery Disease · completed
NCT04356027 — FUnctional diagnoSIs of corONary Stenosis (FUSION) · completed
NCT04375319 — OCT Evaluation of Early Vascular Repair in Patients With Non ST Elevation Acute Coronary Syndrome (NSTE-ACS) · NA · unknown

Other recruiting trials for Head and Neck Cancer

Currently open trials in the same condition.

NCT07318220 — Prehabilitation Protocol for Head and Neck Cancer Patients · NA · recruiting
NCT07524114 — Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception · recruiting
NCT07467083 — Development and Application of a Nurse-Led Preemptive Symptom Management Protocol for Head and Neck Cancer Patients Unde · Phase 3 · recruiting
NCT07209189 — Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-esca · Phase 2 · recruiting
NCT06837480 — Photobiomodulation in Head and Neck Cancer-Related Chronic Lymphedema · NA · recruiting

Other Krankenhaus Barmherzige Schwestern Linz trials

Trials by the same sponsor.

NCT06768541 — Subsidence of Short Stem THA With DORR Type C · completed
NCT06815796 — Loop Vs. Anchor Tenodesis of the Long Head of the Biceps Brachii Tendon · NA · active not recruiting
NCT04918888 — COVID-19 Vaccination in Oncologic Patients · completed
NCT04400578 — TRICIN: Prospective Study on the Efficacy of Single Topical Trichloroacetic Acid (TCA) 85% in the Treatment of Cervical · NA · completed
NCT06430723 — The Impact of Obesity on Short Stem Total Hip Arthroplasty · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04610645 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Krankenhaus Barmherzige Schwestern Linz
Last refreshed: 3 March 2026

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04610645.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing