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NCT04609657
Liking Adaptation to Beverages With Varying Sweetness Levels After Prolonged Exposure
NA trial testing Flavored carbonated soft drink (CSD) in Sweetness Liking Adaptation in 168 participants. Completed in 25 May 2021.
25 May 2021
Quick facts
| Lead sponsor | PepsiCo Global R&D |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | basic science |
| Enrollment | 168 |
| Start date | 10 November 2020 |
| Primary completion | 25 May 2021 |
| Estimated completion | 25 May 2021 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Flavored carbonated soft drink (CSD)
Conditions studied
- Sweetness Liking Adaptation — all drugs for Sweetness Liking Adaptation →
Sponsor
PepsiCo Global R&D — full company profile →
Who can join
Adults 25 to 55, any sex, with Sweetness Liking Adaptation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a double-blind, controlled, parallel, randomized sensory study. The study will consist of two cohorts; habitual regular full-calorie Carbonated Soft Drink (CSD) consumers and habitual low-calorie CSD consumers. Each cohort will be randomized to one of 3 interventions for six months (24 weeks): * Intervention 1: Control (full sweetness) beverage * Intervention 2: Step-wise sweetness reduction series of beverages * Intervention 3: Moderate sweetness (reduced sweetness) beverage The primary outcome is to assess the perception changes in sweetness (magnitude scale) and sweetness liking (Likert scale) of a test product and a control product over a period of six months. The study endeavors to explore whether consumers of sweetened carbonated beverages can adapt liking to lower sweetness beverages after prolonged exposure of daily consumption of beverages with step-wise reduction of sweetness, or maintenance at reduced (moderate) sweetness. Additional analysis will be to assess dietary compensation for sweetness in the step-wise and moderate reduction arms compared to the control arms (the full calorie and low calorie control beverages). Dietary analysis of calories and intakes of total sugar, added sugar, and servings of low-/non-calorie sweeteners will be assessed using a 3-day diet record pre-intervention and monthly for 6 months.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Change in liking following reduction in sweetness level of carbonated beverages: a randomized controlled parallel trial.
Mah E, Kamil A, Blonquist TM, Rehm CD, et al · · 2024 · cited 3× · PMID 39500957 · DOI 10.1038/s41598-024-77529-w
Verify or expand the search:
- PubMed search for NCT04609657
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Flavored carbonated soft drink (CSD)
Trials testing the same drug.
- NCT04284462 — Liking Adaptation to Beverages of Varying Sweetness Levels After Prolonged Exposure · NA · terminated
Other PepsiCo Global R&D trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04609657 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by PepsiCo Global R&D
- Last refreshed: 24 March 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04609657.
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