NCT04608994 is a clinical trial in Post Intensive Care Unit Syndrome, sponsored by Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia.

Who is sponsoring NCT04608994?

NCT04608994 is sponsored by Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia.

What condition does NCT04608994 study?

NCT04608994 studies Post Intensive Care Unit Syndrome.

Is NCT04608994 still recruiting?

NCT04608994 is currently status unknown. Last updated 30 October 2020.

Last reviewed 2020-10-30 · How we verify

NCT04608994

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Long-term Follow up in Survivors of Critical Illness

Status unknown Last updated 30 October 2020

What this trial tests

trial in Post Intensive Care Unit Syndrome in 160 participants. Status unknown.

Timeline

1 June 2020

Primary endpoint
1 June 2021

1 July 2021

Quick facts

Lead sponsor	Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Status	Status unknown
Study type	OBSERVATIONAL
Enrollment	160
Start date	1 June 2020
Primary completion	1 June 2021
Estimated completion	1 July 2021
Sites	1 location across Italy

Conditions studied

Post Intensive Care Unit Syndrome — all drugs for Post Intensive Care Unit Syndrome →

Sponsor

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia — full company profile →

Who can join

Eligibility, any sex, with Post Intensive Care Unit Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Survivors of critical illness may suffer from persistent physical, cognitive and mental impairments, such as muscle weakness, dysfunction in the memory and executive domains, post-traumatic stress disorders, depression, and anxiety. This syndrome is referred to as Post Intensive Care Syndrome (PICS). This study aims to assess the frequency of impairments, their evolution over time, and to understand the pathogenetic mechanisms and the association between long-term sequelae and acute care events.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Physical, cognitive and mental health outcomes in 1-year survivors of COVID-19-associated ARDS.
Latronico N, Peli E, Calza S, Rodella F, et al · · 2022 · cited 115× · PMID 34588274 · DOI 10.1136/thoraxjnl-2021-218064
Long-Term Physical, Cognitive, and Psychological Outcomes in Severe COVID-19 Patients Managed With Extracorporeal Membrane Oxygenation: A Prospective Study.
Pozzi M, Giani M, Andreossi M, Annoni A, et al · · 2023 · cited 9× · PMID 37531088 · DOI 10.1097/mat.0000000000001997
Hospital Memories and Six-Month Psychological Outcome: A Prospective Study in Critical Ill Patients with COVID-19 Respiratory Failure.
Pozzi M, Ripa C, Meroni V, Ferlicca D, et al · · 2023 · cited 6× · PMID 37176785 · DOI 10.3390/jcm12093344
Long-term alveolar-capillary diffusion impairments after severe SARS-CoV-2 pneumonia.
Pini L, Giordani J, Levi G, Guerini M, et al · · 2025 · cited 2× · PMID 40152750 · DOI 10.1080/07853890.2025.2483383
Electrophysiological neuromuscular alterations and severe fatigue predict long-term muscle weakness in survivors of COVID-19 acute respiratory distress syndrome.
Benedini M, Cogliati M, Lulic-Kuryllo T, Peli E, et al · · 2023 · cited 2× · PMID 38073634 · DOI 10.3389/fneur.2023.1235734
Three-Month Outcome in Survivors of COVID-19 Associated Acute Respiratory Distress Syndrome
Latronico N, Peli E, Rodella F, Novelli MP, et al · · 2021 · cited 2× · DOI 10.2139/ssrn.3749226
Six-Month Outcome in Survivors of COVID-19 Associated Acute Respiratory Distress Syndrome
Latronico N, Peli E, Rodella F, Novelli MP, et al · · 2020 · cited 1× · DOI 10.2139/ssrn.3756865
24-Month assessment of respiratory function in patients hospitalized for severe SARS-CoV-2 pneumonia: a follow-up study.
Pini L, Guerini M, Giordani J, Levi G, et al · · 2025 · PMID 41182495 · DOI 10.1007/s11739-025-04153-5

Verify or expand the search:

Other Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia trials

Trials by the same sponsor.

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NCT05738902 — Adherence and Compliance to ERAS in Gynecological Surgery · unknown
NCT06765343 — Efficacy of Guided Biofilm Therapy in Pediatric Patient · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04608994 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Last refreshed: 30 October 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04608994.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing