NCT04607941: ComCor

Study of Socio-demographic Factors, Behaviors and Practices Associated With Infection With SARS-CoV-2 Responsible for COVID-19

Completed Last updated 6 April 2023

What this trial tests

trial testing Questionnaires in Covid19 in 766,818 participants. Completed in 30 September 2022.

Timeline

27 October 2020

Primary endpoint
30 September 2022

30 September 2022

Quick facts

Lead sponsor	Institut Pasteur
Status	Completed
Study type	OBSERVATIONAL
Enrollment	766,818
Start date	27 October 2020
Primary completion	30 September 2022
Estimated completion	30 September 2022
Sites	2 locations across France

Drugs / interventions tested

• Questionnaires
• Phone interviews

Conditions studied

• Covid19 — all drugs for Covid19 →

Sponsor

Institut Pasteur — full company profile →

Who can join

18 and older, any sex, with Covid19. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of the study is to identify socio-demographic factors, behaviors and practices associated with infection with SARS-CoV-2 to help determine where and how patients mostly get infected with SARS-CoV-2.

It is a case-control study including :

* cases identified by the nationwide system of positive SARS-CoV-2 tests (COVID-19 diagnosis information system, SIDEP) (currently limited to qRT-PCR) and invited to participate by the National Health Insurance (CNAM) which hosts the data from the nationwide test system;
* controls included via Ipsos, a polling institute with access to personal data from a panel from which they will include controls matched on age (divided into 10-year categories), gender and geographic area (departement);
* cases will be offered to invite a person they live with to participate in the study offering another case-control analysis inside a household. These participants will be required to report the result of the test as recommended by contact tracing guidelines to determine whether they are cases or controls.

Data will be collected via a self-administered online questionnaire. Some of the participants will be called for a complementary telephone questionnaire to measure reliability of online retrieved data and explore more specific aspects of SARS-CoV-2 transmission.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Impact of SARS-CoV-2 Delta variant on incubation, transmission settings and vaccine effectiveness: Results from a nationwide case-control study in France.
   Grant R, Charmet T, Schaeffer L, Galmiche S, et al · · 2022 · cited 110× · PMID 34849500 · DOI 10.1016/j.lanepe.2021.100278
2. Impact of original, B.1.1.7, and B.1.351/P.1 SARS-CoV-2 lineages on vaccine effectiveness of two doses of COVID-19 mRNA vaccines: Results from a nationwide case-control study in France.
   Charmet T, Schaeffer L, Grant R, Galmiche S, et al · · 2021 · cited 66× · PMID 34278372 · DOI 10.1016/j.lanepe.2021.100171
3. Exposures associated with SARS-CoV-2 infection in France: A nationwide online case-control study.
   Galmiche S, Charmet T, Schaeffer L, Paireau J, et al · · 2021 · cited 64× · PMID 34124709 · DOI 10.1016/j.lanepe.2021.100148
4. SARS-CoV-2 incubation period across variants of concern, individual factors, and circumstances of infection in France: a case series analysis from the ComCor study.
   Galmiche S, Cortier T, Charmet T, Schaeffer L, et al · · 2023 · cited 57× · PMID 37084751 · DOI 10.1016/s2666-5247(23)00005-8
5. SARS-CoV-2 exposures of healthcare workers from primary care, long-term care facilities and hospitals: a nationwide matched case-control study.
   Belan M, Charmet T, Schaeffer L, Tubiana S, et al · · 2022 · cited 20× · PMID 35777605 · DOI 10.1016/j.cmi.2022.05.038
6. Risk of SARS-CoV-2 Infection Among Households With Children in France, 2020-2022.
   Galmiche S, Charmet T, Rakover A, Schaeffer L, et al · · 2023 · cited 7× · PMID 37713194 · DOI 10.1001/jamanetworkopen.2023.34084
7. Reduction of SARS-CoV-2 intra-household child-to-parent transmission associated with ventilation: results from a case-control study.
   Galmiche S, Charmet T, Madec Y, Rakover A, et al · · 2023 · cited 2× · PMID 37365557 · DOI 10.1186/s12889-023-16144-2
8. SARS-CoV-2 self-test uptake and factors associated with self-testing during Omicron BA.1 and BA.2 waves in France, January to May 2022.
   Supplisson O, Charmet T, Galmiche S, Schaeffer L, et al · · 2023 · cited 2× · PMID 37140451 · DOI 10.2807/1560-7917.es.2023.28.18.2200781