NCT04606979

tDCS of the Primary Motor Cortex to Improve Implicit Motor Sequence Learning in Parkinson's Disease

Status unknown NA Last updated 2 May 2022

What this trial tests

NA trial testing 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS) in Parkinson Disease in 30 participants. Status unknown.

Timeline

11 October 2020

Primary endpoint
31 August 2022

31 August 2022

Quick facts

Lead sponsor	Vrije Universiteit Brussel
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	30
Start date	11 October 2020
Primary completion	31 August 2022
Estimated completion	31 August 2022
Sites	1 location across Belgium

Drugs / interventions tested

• 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS)

Conditions studied

• Parkinson Disease — all drugs for Parkinson Disease →
• Parkinson — all drugs for Parkinson →
• Healthy — all drugs for Healthy →

Sponsor

Vrije Universiteit Brussel — full company profile →

Who can join

55 and older, any sex, with Parkinson Disease or Parkinson. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Implicit motor sequence learning (IMSL) is a form of cognitive function that is known to be directly associated with impaired motor function in Parkinson's disease (PD). Research in healthy young participants shows the potential for transcranial direct current stimulation (tDCS), a non-invasive brain stimulation technique, over the primary motor cortex (M1) to enhance IMSL. tDCS has direct effects on the underlying cortex, but also induces distant (basal ganglia) network effects - hence its potential value in PD, a prime model of basal ganglia dysfunction. To date, however, only null-effects have been reported in persons with PD. In the present study, the investigators will investigate the potential of tDCS delivered over M1 to enhance IMSL, as measured by the Serial Reaction Time task, in persons with PD. The investigators will determine immediate effects that may occur concurrently with the application of tDCS but also short-term (five minutes post-tDCS) and long-term (one week post-tDCS) consolidation effects, as previous studies suggest that tDCS exerts its beneficial effects on IMSL in a consolidation phase rather than in an acquisition phase. Establishing possible consolidation effects is of a particular interest, as long-term effects are vital for the successful functional rehabilitation of persons with PD.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.