NCT04605263 (PPNGB01) is a NA clinical trial of STN-PPN DBS Surgery in Parkinson Disease, sponsored by St. Joseph's Hospital and Medical Center, Phoenix.

Who is sponsoring NCT04605263?

NCT04605263 is sponsored by St. Joseph's Hospital and Medical Center, Phoenix.

What drugs are being tested in NCT04605263?

Interventions in NCT04605263: STN-PPN DBS Surgery, Deep Brain Stimulation Surgery (DBS).

What condition does NCT04605263 study?

NCT04605263 studies Parkinson Disease.

Is NCT04605263 still recruiting?

NCT04605263 is currently enrolling by invitation. Last updated 29 November 2024.

Last reviewed 2024-11-29 · How we verify

NCT04605263: PPNGB01

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Deep Brain Stimulation (DBS) of the Pedunculopontine Nucleus (PPN)

ENROLLING BY INVITATION NA Last updated 29 November 2024

What this trial tests

NA trial testing STN-PPN DBS Surgery in Parkinson Disease in 8 participants. Enrolling by invitation.

Timeline

1 November 2021

Primary endpoint
1 September 2026

1 September 2027

Quick facts

Lead sponsor	St. Joseph's Hospital and Medical Center, Phoenix
Phase	NA
Status	ENROLLING BY INVITATION
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	triple
Primary purpose	treatment
Enrollment	8
Start date	1 November 2021
Primary completion	1 September 2026
Estimated completion	1 September 2027
Sites	1 location across United States

Drugs / interventions tested

STN-PPN DBS Surgery
Deep Brain Stimulation Surgery (DBS)

Conditions studied

Parkinson Disease — all drugs for Parkinson Disease →

Sponsor

St. Joseph's Hospital and Medical Center, Phoenix

Who can join

Adults 18 to 75, any sex, with Parkinson Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a mechanistic study to determine the differential effects of the dopaminergic and cholinergic systems on attention, gait, and balance. The primary goal of the study is to evaluate the relative effects of pedunculopontine nucleus (PPN) and subthalamic nucleus (STN) Deep Brain Stimulation (DBS) on these features in persons with Parkinson's Disease (PD) who are eligible for DBS for improvement of their motor symptoms and exhibit gait instability with falls. Patients will be enrolled and implanted with bilateral electrodes in one of the approved DBS locations (subthalamic nucleus: STN), but additionally electrodes will be inserted into the experimental target, namely the PPN bilaterally.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

What is new in Freezing of Gait?
Gülke E, Lewis SJG. · · 2026 · PMID 41865085 · DOI 10.1007/s00415-026-13765-6

Verify or expand the search:

Other recruiting trials for Parkinson Disease

Currently open trials in the same condition.

NCT07399496 — Accelerated TMS for Apathy in PD · NA · recruiting
NCT07371338 — Phase 1 Clinical Trial to Evaluate the Safety, Efficacy, and Pharmacokinetics of IPS101A in Parkinson's Disease Patients · Phase 1 · recruiting
NCT07442370 — The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients · NA · recruiting
NCT06848205 — Percept Transitions in FOG and PD · NA · recruiting
NCT07432958 — A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (P · Phase 2 · recruiting

Other St. Joseph's Hospital and Medical Center, Phoenix trials

Trials by the same sponsor.

NCT06177028 — MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairment · Phase 2 · not yet recruiting
NCT06734286 — Working Memory Training in Patients with Mild Cognitive Impairment · NA · recruiting
NCT06578195 — ASSESS ALL ALS Study · recruiting
NCT06581861 — PREVENT ALL ALS Study · recruiting
NCT06019793 — Electrophysiological Recordings from Deep Brain Stimulation Electrodes for Pain · NA · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04605263 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by St. Joseph's Hospital and Medical Center, Phoenix
Last refreshed: 29 November 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04605263.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing