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NCT04599894
Reducing Postoperative Side Effect of Pregabalin
Phase 4 trial testing 37.5mg Pregabalin + 75mg Pregabalin in Pain, Postoperative in 58 participants. Completed in 4 May 2021.
30 April 2021
Quick facts
| Lead sponsor | The First Hospital of Jilin University |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 58 |
| Start date | 1 November 2020 |
| Primary completion | 30 April 2021 |
| Estimated completion | 4 May 2021 |
| Sites | 1 location across China |
Drugs / interventions tested
- 37.5mg Pregabalin + 75mg Pregabalin — full drug profile →
- 75mg Pregabalin — full drug profile →
Conditions studied
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Arthroplasty, Replacement, Knee — all drugs for Arthroplasty, Replacement, Knee →
- Arthroplasty, Replacement, Hip — all drugs for Arthroplasty, Replacement, Hip →
Sponsor
The First Hospital of Jilin University
Who can join
Adults 21 to 80, any sex, with Pain, Postoperative or Arthroplasty, Replacement, Knee. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study was to determine 1) if pregabalin, when given 37.5 mg twice on the day before surgery, would be effective in reducing the early postoperative side effects including dizziness, nausea, vomiting and sedation of receiving pregabalin 75mg two hours pre-operatively and 75mg per day until the third postoperative day; and 2) whether this intervention affected the opioids consumption, and independent transfers at six hours post-op, time to readiness for independent transfers, time to readiness for discharge and pain or not.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04599894
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04599894 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The First Hospital of Jilin University
- Last refreshed: 26 October 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04599894.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing