Last reviewed · How we verify
NCT04599088
Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging
NA trial testing Brain functional MRI with simplified urodynamics in Urgency Urinary Incontinence in 207 participants. Participants enrolled and being followed up; not accepting new ones.
31 July 2025
Quick facts
| Lead sponsor | University of Pittsburgh |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | other |
| Enrollment | 207 |
| Start date | 14 December 2020 |
| Primary completion | 31 July 2025 |
| Estimated completion | 1 April 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Brain functional MRI with simplified urodynamics
Conditions studied
- Urgency Urinary Incontinence — all drugs for Urgency Urinary Incontinence →
Sponsor
University of Pittsburgh
Who can join
18 and older, female only, with Urgency Urinary Incontinence. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent counterparts. This will expand the investigators current knowledge of how the brain controls the bladder, how that control changes with age and disease, and suggest new targets to guide development of better treatment.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement.
Tenchov R, Sasso JM, Wang X, Zhou QA. · · 2024 · cited 113× · PMID 38095562 · DOI 10.1021/acschemneuro.3c00531
Verify or expand the search:
- PubMed search for NCT04599088
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Urgency Urinary Incontinence
Currently open trials in the same condition.
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- NCT05512039 — Reduced-dose Botox for Urgency Incontinence Among Elder Females · Phase 1, PHASE2 · active not recruiting
- NCT05604222 — Effect of Behavioral Sleep Intervention on Lower Urinary Tract Symptoms in Older Women · Phase 4 · recruiting
- NCT04731961 — Reduction in Number of Botox Injections for Urgency Urinary Incontinence · NA · recruiting
Other University of Pittsburgh trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04599088 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Pittsburgh
- Last refreshed: 17 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04599088.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing