NCT04597801 (INVIVO) is a Phase 2 clinical trial of Alcon in Intracranial Tumor, sponsored by Technical University of Munich.

Who is sponsoring NCT04597801?

NCT04597801 is sponsored by Technical University of Munich.

What drugs are being tested in NCT04597801?

Interventions in NCT04597801: Alcon.

What condition does NCT04597801 study?

NCT04597801 studies Intracranial Tumor.

Is NCT04597801 still recruiting?

NCT04597801 is currently completed. Last updated 10 November 2022.

Last reviewed 2022-11-10 · How we verify

NCT04597801: INVIVO

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Comparison of Fluorescein-INtra-VItal Microscopy Versus Conventional Frozen Section Diagnosis for intraOperative Histopathological Evaluation

Completed Phase 2 Last updated 10 November 2022

What this trial tests

Phase 2 trial testing Alcon in Intracranial Tumor in 210 participants. Completed in 3 August 2022.

Timeline

30 December 2020

Primary endpoint
17 June 2022

3 August 2022

Quick facts

Lead sponsor	Technical University of Munich
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	diagnostic
Enrollment	210
Start date	30 December 2020
Primary completion	17 June 2022
Estimated completion	3 August 2022
Sites	3 locations across Germany

Drugs / interventions tested

Alcon — full drug profile →

Conditions studied

Intracranial Tumor — all drugs for Intracranial Tumor →

Sponsor

Technical University of Munich

Who can join

18 and older, any sex, with Intracranial Tumor. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

With the appliance of the in-vivo microscopy after Fluorescein staining, the investigators hypothesize that the preliminary in-vivo histopathological diagnostic accuracy is not inferior to conventional frozen section analysis accuracy when using the final histopathological result as gold standard.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Confocal laser imaging in neurosurgery: A comprehensive review of sodium fluorescein-based CONVIVO preclinical and clinical applications.
Restelli F, Mathis AM, Höhne J, Mazzapicchi E, et al · · 2022 · cited 20× · PMID 36263218 · DOI 10.3389/fonc.2022.998384
Intraoperative confocal laser endomicroscopy for brain tumors - potential and challenges from a neuropathological perspective.
Maragkou T, Quint K, Pollo B, Hewer E. · · 2022 · cited 7× · PMID 37284159 · DOI 10.17879/freeneuropathology-2022-4369
Current and Emerging Fluorescence-Guided Techniques in Glioma to Enhance Resection.
Nguyen TTT, Mnatsakanyan H, Yi E, Badr CE. · · 2025 · cited 1× · PMID 40867331 · DOI 10.3390/cancers17162702

Verify or expand the search:

Other recruiting trials for Intracranial Tumor

Currently open trials in the same condition.

NCT07063693 — ABY-029 Glioma Trial · Phase 1 · recruiting

Other Technical University of Munich trials

Trials by the same sponsor.

NCT07519811 — LLM-Generated Plain-Language Patient Synopses to Improve Comprehension in Hematology and Oncology (oncOPAL) · NA · recruiting
NCT06650995 — AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure · NA · recruiting
NCT07077005 — Mavacamten Enables Exercise in Hypertrophic Obstructive Cardiomyopathy · NA · recruiting
NCT07212699 — Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App · NA · recruiting
NCT06823271 — Haemodynamics and Ventricular Arrhythmias During Exercise in Patients With Arrhythmogenic Cardiomyopathy · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04597801 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Technical University of Munich
Last refreshed: 10 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04597801.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing