Who is sponsoring NCT04597606?

NCT04597606 is sponsored by Javier Sayas Catalan.

What drugs are being tested in NCT04597606?

Interventions in NCT04597606: Exercise with spontaneous ventilation., Exercise with NIV, Exercise with HFNC.

What condition does NCT04597606 study?

NCT04597606 studies Pulmonary Disease, Chronic Obstructive.

Is NCT04597606 still recruiting?

NCT04597606 is currently completed. Last updated 23 November 2022.

Last reviewed 2022-11-23 · How we verify

NCT04597606: HFNIV

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Respiratory Drive Response in COPD Patients During Exercise With Non Invasive Ventilation (NIV).

Completed Last updated 23 November 2022

What this trial tests

trial testing Exercise with spontaneous ventilation. in Pulmonary Disease, Chronic Obstructive in 12 participants. Completed in 15 November 2022.

Timeline

2 September 2019

Primary endpoint
15 November 2022

15 November 2022

Quick facts

Lead sponsor	Javier Sayas Catalan
Status	Completed
Study type	OBSERVATIONAL
Enrollment	12
Start date	2 September 2019
Primary completion	15 November 2022
Estimated completion	15 November 2022
Sites	1 location across Spain

Drugs / interventions tested

Exercise with spontaneous ventilation.
Exercise with NIV
Exercise with HFNC

Conditions studied

Pulmonary Disease, Chronic Obstructive — all drugs for Pulmonary Disease, Chronic Obstructive →

Sponsor

Javier Sayas Catalan

Who can join

18 and older, any sex, with Pulmonary Disease, Chronic Obstructive. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A constant load exercise during 10 minutes will be performed in a group of Chronic Obstructive Pulmonary Disease patients, in a basal condition (spontaneous breathing); under noninvasive mask ventilation and with high flow nasal cannula. With the aim of reducing dyspnea, increasing exercise tolerance, and unload respiratory muscles, three exercises will be compared in terms of use of respiratory muscles and neural drive measured with paraesternal electromyography.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Measurement of thoraco-abdominal synchrony using respiratory inductance plethysmography: technical aspects and a proposal to overcome its limitations.
Sayas J, Lalmolda C, Corral M, Flórez P, et al · · 2024 · cited 3× · PMID 38829281 · DOI 10.1080/17476348.2024.2363058
Muscle Unloading During Exercise: Comparative Effects of Conventional Oxygen, NIV, and High-Flow Therapy on Neural Drive in Severe COPD.
Sayas-Catalán J, Villena Garrido V, Lalmolda C, Hernández-Voth A, et al · · 2025 · PMID 41303187 · DOI 10.3390/jcm14228150

Verify or expand the search:

Other recruiting trials for Pulmonary Disease, Chronic Obstructive

Currently open trials in the same condition.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04597606 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Javier Sayas Catalan
Last refreshed: 23 November 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04597606.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing