Who is sponsoring NCT04594837?

NCT04594837 is sponsored by NextStep Robotics Inc..

What drugs are being tested in NCT04594837?

Interventions in NCT04594837: PTR Physical Therapy while wearing Robot group (Phase II), Physical Therapy Only (Phase II), Cross over group for Physical Therapy n Sub-Acute group. (Phase II), Chronic Stroke Subjects to receive robotic gait training therapy..

What condition does NCT04594837 study?

NCT04594837 studies Foot Drop, Stroke, Hemiparesis.

Is NCT04594837 still recruiting?

NCT04594837 is currently status unknown. Last updated 26 January 2023.

Last reviewed 2023-01-26 · How we verify

NCT04594837

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ankle Robotics After Stroke

Status unknown NA Last updated 26 January 2023

What this trial tests

NA trial testing PTR Physical Therapy while wearing Robot group (Phase II) in Foot Drop in 140 participants. Status unknown.

Timeline

20 August 2020

Primary endpoint
28 February 2025

28 February 2025

Quick facts

Lead sponsor	NextStep Robotics Inc.
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	140
Start date	20 August 2020
Primary completion	28 February 2025
Estimated completion	28 February 2025
Sites	1 location across United States

Drugs / interventions tested

PTR Physical Therapy while wearing Robot group (Phase II)
Physical Therapy Only (Phase II)
Cross over group for Physical Therapy n Sub-Acute group. (Phase II)
Chronic Stroke Subjects to receive robotic gait training therapy.

Conditions studied

Foot Drop — all drugs for Foot Drop →
Stroke — all drugs for Stroke →
Hemiparesis — all drugs for Hemiparesis →

Sponsor

NextStep Robotics Inc.

Who can join

18 and older, any sex, with Foot Drop or Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The randomized study (in Phase II of the U44) compares the efficacy and durability of 9 weeks (18 sessions) of robot-assisted physical therapy (PTR) versus physical therapy (PT) alone on foot drop as assessed by gait biomechanics (ankle angle at initial contact, peak swing ankle angle, number of heel-first strikes - % total steps, gait velocity) and blinded clinician assessment (dorsiflexion active range of motion, ankle muscle strength, assistive device needs).

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Adaptive control ankle robotics training durably improves gait biomechanics in chronic hemiparetic stroke and footdrop.
Roy A, Hennessie B, Hafer-Macko C, Forrester LW, et al · · 2025 · PMID 41462280 · DOI 10.1186/s12984-025-01834-2
Dorsiflexion Specific Ankle Robotics to Enhance Motor Learning After Stroke: A Preliminary Report
Roy A, Hennessie B, Hafer-Macko C, Westlake K, et al · · 2024 · DOI 10.21203/rs.3.rs-4390770/v1

Verify or expand the search:

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04594837 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by NextStep Robotics Inc.
Last refreshed: 26 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04594837.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing