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NCT04594785: RIPI
Evaluation of Post Infectious Inflammatory Reaction (PIIR) Concerning Children After Streptococcus Pneumoniae, Streptococcus Pyogenes and Neisseria Meningococcus Invasive Infection
trial in Streptococcus Pneumonia in 150 participants. Status unknown.
1 December 2021
Quick facts
| Lead sponsor | University Hospital, Montpellier |
|---|---|
| Status | Status unknown |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 1 October 2020 |
| Primary completion | 1 December 2021 |
| Estimated completion | 30 December 2021 |
| Sites | 1 location across France |
Conditions studied
- Streptococcus Pneumonia — all drugs for Streptococcus Pneumonia →
- Streptococcus Pyogenes Infection — all drugs for Streptococcus Pyogenes Infection →
- Neisseria Meningitides Meningitis — all drugs for Neisseria Meningitides Meningitis →
Sponsor
University Hospital, Montpellier
Who can join
Under 18, any sex, with Streptococcus Pneumonia or Streptococcus Pyogenes Infection. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
As Covid 19 manifestations that have been recently described, inflammatory manifestation have major impact in infectious disease lesions. Some of them are delayed and provide Post infectious inflammatory reaction (PIIR), they are challenging for diagnosis and for management. Clinician have to avoid unnecessary antibiotic thearapy and in if necessary have to give immunosuppressive therapy. Except for rheumatic disease for group A streptococcus (GAS) infections there are not stanrdized diagnostic criteria and therapeutic protocol, and PIIR have probably a suboptimal management. In this context the investigators aim to explore PIIR in the 3 most frequent bacterial invasive infection in France, by a retrospective monocentric study. The investigators include all children betwwen 2012 and 2018 hospitalized for infections by Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), and GAS invasive infections.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Evaluation of post-infectious inflammatory reactions in a retrospective study of 3 common invasive bacterial infections in pediatrics.
Abraham P, Marin G, Filleron A, Michon AL, et al · · 2022 · cited 4× · PMID 36197203 · DOI 10.1097/md.0000000000030506
Verify or expand the search:
- PubMed search for NCT04594785
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
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Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04594785 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Montpellier
- Last refreshed: 28 October 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04594785.
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