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NCT04594408
Tranexamic Acid to Improve Arthroscopic Visualization in Shoulder Surgery
Phase 4 trial testing Epinephrine in Rotator Cuff Injuries in 128 participants. Completed in 1 January 2024.
1 October 2021
Quick facts
| Lead sponsor | Panam Clinic |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 128 |
| Start date | 1 September 2020 |
| Primary completion | 1 October 2021 |
| Estimated completion | 1 January 2024 |
| Sites | 1 location across Canada |
Drugs / interventions tested
- Epinephrine (epinephrine) — full drug profile →
- Tranexamic acid (Tranexamic Acid) — full drug profile →
- Epinephrine and Tranexamic Acid — full drug profile →
Conditions studied
- Rotator Cuff Injuries — all drugs for Rotator Cuff Injuries →
- Rotator Cuff Tears — all drugs for Rotator Cuff Tears →
- Subacromial Impingement — all drugs for Subacromial Impingement →
- Subacromial Impingement Syndrome — all drugs for Subacromial Impingement Syndrome →
Sponsor
Panam Clinic
Who can join
18 and older, any sex, with Rotator Cuff Injuries or Rotator Cuff Tears. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to determine if intravenous TXA is a safe alternative to epinephrine in improving arthroscopic shoulder visualization. Primary Objectives 1. Determine that patients given intravenous tranexamic acid improves surgeon-rated visualization compared to placebo. 2. Determine that intravenous tranexamic acid is a safe alternative to epinephrine mixed irrigation fluid to improve arthroscopic shoulder visualization
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04594408
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Epinephrine
Trials testing the same drug.
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- NCT05738148 — Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation · Phase 1 · active not recruiting
- NCT06013150 — Study of Inhaled DMC-IH1 and Intramuscular (EpiPen®) Epinephrine in Healthy Male and Female Participants. · Phase 1 · completed
Other recruiting trials for Rotator Cuff Injuries
Currently open trials in the same condition.
- NCT07501013 — Clinical Outcomes of Arthroscopic Surgeries for Shoulder and Knee Sports Injuries · recruiting
- NCT07294729 — Mulligan and Proprioceptive Neuromuscular Facilitation Techniques in Individuals With Rotator Cuff Lesions · NA · active not recruiting
- NCT07135375 — Postoperative Rotator Cuff Rehabilitation: Functional, Pain and Sleep Quality · NA · recruiting
- NCT07348016 — Safety and Efficacy of Platelet-Rich Plasma Combined With Compound Betamethasone in Arthroscopic Surgery for Rotator Cuf · NA · recruiting
- NCT07228936 — The Role of Pectoralis Minor Tightness in the Development of Rotator Cuff Tears · recruiting
Other Panam Clinic trials
Trials by the same sponsor.
- NCT05280899 — Weightbearing Restrictions on Postoperative Outcomes Following Arthroscopic Surgery for FAI · NA · recruiting
- NCT05151965 — Return to Sport and Functional Performance Following Surgical Intervention for Anterior Glenohumeral Instability · recruiting
- NCT04728282 — Comparison of Lateralized RTSA With and Without Subscapularis Repair · NA · recruiting
- NCT03878862 — Surgical Management of Irreparable RC Tears · recruiting
- NCT03671421 — Number One Overall Graft Pick? Hamstring vs Bone-Patellar-Tendon-Bone vs Quadriceps Tendon · NA · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04594408 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Panam Clinic
- Last refreshed: 2 April 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04594408.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing