Last reviewed · How we verify
NCT04589676
Developing and Testing the Opioid Rapid Response System
NA trial testing Naloxone training in Opioid Overdose in 400 participants. Completed in 31 December 2021.
31 December 2021
Quick facts
| Lead sponsor | Real Prevention, LLC |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 400 |
| Start date | 1 December 2020 |
| Primary completion | 31 December 2021 |
| Estimated completion | 31 December 2021 |
| Sites | 2 locations across United States |
Drugs / interventions tested
- Naloxone training
Conditions studied
- Opioid Overdose — all drugs for Opioid Overdose →
Sponsor
Real Prevention, LLC
Who can join
18 and older, any sex, with Opioid Overdose. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This Phase I SBIR will develop and demonstrate the usability/feasibility of the Opioid Rapid Response System (OSSR) in order to reduce deaths and strain on emergency response systems from opioid overdoses.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Developing the Opioid Rapid Response System™ for Lay Citizen Response to the Opioid Overdose Crisis: a Randomized Controlled Trial.
Hecht ML, Jayawardene W, Henderson C, Pezalla A, et al · · 2023 · cited 6× · PMID 37737966 · DOI 10.1007/s11121-023-01588-0 -
Development of opioid rapid response system: Protocol for a randomized controlled trial.
Jayawardene W, Pezalla A, Henderson C, Hecht M. · · 2022 · cited 3× · PMID 35296414 · DOI 10.1016/j.cct.2022.106727
Verify or expand the search:
- PubMed search for NCT04589676
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Opioid Overdose
Currently open trials in the same condition.
- NCT07079241 — A Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose · NA · recruiting
- NCT06806163 — Machine-Learning Prediction and Reducing Overdoses With EHR Nudges · NA · recruiting
- NCT06593093 — A Bundled Intervention · Phase 1, PHASE2 · recruiting
- NCT06429436 — Vending Machine Naloxone Distribution for Your Community (VENDY) · Phase 4 · recruiting
- NCT05877118 — Improving Availability of Intranasal Naloxone · NA · recruiting
Other Real Prevention, LLC trials
Trials by the same sponsor.
- NCT03932097 — REAL Parenting Alcohol and Substance Use App · NA · completed
- NCT05209191 — Reducing High School Athletes' Prescription Opioids Misuse and Diversion Through the Student Athlete Wellness Portal · NA · completed
- NCT03491865 — Peer-to-peer Tobacco and ENDS Prevention · NA · withdrawn
- NCT03157700 — Interactive Technology for Media Literacy Drug Prevention in Community Groups · NA · completed
- NCT03497936 — Marketability of a Technology-based Intervention to Increase HPV Vaccination · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04589676 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Real Prevention, LLC
- Last refreshed: 7 February 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04589676.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing