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NCT04586816
Randomized, Double-Blind Evaluation of Maple Leaf Extract (Maplifa) for Photoaging
NA trial testing 1% red maple leaf extract in cream base in Photoaging in 19 participants. Completed in 15 January 2020.
15 January 2020
Quick facts
| Lead sponsor | Integrative Skin Science and Research |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 19 |
| Start date | 10 September 2019 |
| Primary completion | 15 January 2020 |
| Estimated completion | 15 January 2020 |
| Sites | 1 location across United States |
Drugs / interventions tested
- 1% red maple leaf extract in cream base
- 5% red maple leaf extract
- vehicle
Conditions studied
- Photoaging — all drugs for Photoaging →
- Hyperpigmentation — all drugs for Hyperpigmentation →
- Rhytides — all drugs for Rhytides →
Sponsor
Integrative Skin Science and Research
Who can join
Adults 30 to 70, female only, with Photoaging or Hyperpigmentation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Recent research has reported that the maple leaf extract exhibits anti-aging effects by inhibiting elastase activity, thereby preventing the breakdown of elastin and interfering with the formation of wrinkles. Red maple leaf extract contains phenolic compounds known as glucitol-core-containing gallotannins (GCGs) which help reduce the appearance of wrinkles and may decrease skin inflammation, dark spots and pigmentation. The objective of this study is to examine the effects of topical Maplifa on the cosmetic appearance of facial lines, redness and skin tone.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Harnessing Nature's Toolbox: Naturally Derived Bioactive Compounds in Nanotechnology Enhanced Formulations.
Sanjai C, Gaonkar SL, Hakkimane SS. · · 2024 · cited 10× · PMID 39494011 · DOI 10.1021/acsomega.4c07756
Verify or expand the search:
- PubMed search for NCT04586816
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Integrative Skin Science and Research trials
Trials by the same sponsor.
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- NCT06146140 — Effects of an Oral Herbal Supplement on Skin Aging, Hydration, and Elasticity · NA · unknown
- NCT06072066 — Effects of Oral Supplement Containing L-Histidine and Antioxidants on the Skin Barrier Function and Systemic Inflammatio · NA · recruiting
- NCT06142487 — Assessment of the Effects of Silk Pillowcases on Acne Prone Skin · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04586816 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Integrative Skin Science and Research
- Last refreshed: 14 October 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04586816.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing