NCT04581421 (LICARB) is a NA clinical trial of High Carb Low Fat Diet in NAFLD, sponsored by Hvidovre University Hospital.

Who is sponsoring NCT04581421?

NCT04581421 is sponsored by Hvidovre University Hospital.

What drugs are being tested in NCT04581421?

Interventions in NCT04581421: High Carb Low Fat Diet, Low Carb High Fat Diet.

What condition does NCT04581421 study?

NCT04581421 studies NAFLD, Overweight and Obesity, Metabolic Syndrome, Diabetes.

Is NCT04581421 still recruiting?

NCT04581421 is currently completed. Last updated 23 January 2024.

Last reviewed 2024-01-23 · How we verify

NCT04581421: LICARB

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Role of Dietary Carbohydrate and Fat Availability in the Regulation of Hepatic Lipid Content

Completed NA Last updated 23 January 2024

What this trial tests

NA trial testing High Carb Low Fat Diet in NAFLD in 12 participants. Completed in 15 June 2022.

Timeline

3 December 2020

Primary endpoint
15 June 2022

15 June 2022

Quick facts

Lead sponsor	Hvidovre University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	basic science
Enrollment	12
Start date	3 December 2020
Primary completion	15 June 2022
Estimated completion	15 June 2022
Sites	1 location across Denmark

Drugs / interventions tested

High Carb Low Fat Diet
Low Carb High Fat Diet

Conditions studied

NAFLD — all drugs for NAFLD →
Overweight and Obesity — all drugs for Overweight and Obesity →
Metabolic Syndrome — all drugs for Metabolic Syndrome →
Diabetes — all drugs for Diabetes →

Sponsor

Hvidovre University Hospital

Who can join

Adults 18 to 50, male only, with NAFLD or Overweight and Obesity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this study is to investigate dietary compositions effect on liverfat measured by magnetic resonance imaging.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

The impact of short-term eucaloric low- and high-carbohydrate diets on liver triacylglycerol content in males with overweight and obesity: a randomized crossover study.
London A, Richter MM, Sjøberg KA, Wewer Albrechtsen NJ, et al · · 2024 · cited 15× · PMID 38914224 · DOI 10.1016/j.ajcnut.2024.06.006
Low glycaemic index or low glycaemic load diets for people with overweight or obesity.
Chekima K, Yan SW, Lee SWH, Wong TZ, et al · · 2023 · cited 5× · PMID 37345841 · DOI 10.1002/14651858.cd005105.pub3
Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism.
Lundsgaard AM, Del Giudice R, Kanta JM, Larance M, et al · · 2025 · cited 4× · PMID 40032158 · DOI 10.1016/j.molmet.2025.102119
Tuned by time: the role of circadian rhythms in metabolic energy sensing and chronotherapy.
Thanuskodi Rajakumar A, Kodiveri Muthukaliannan G. · · 2025 · PMID 41339276 · DOI 10.1080/07853890.2025.2596548

Verify or expand the search:

Other recruiting trials for NAFLD

Currently open trials in the same condition.

NCT07518784 — Accurate Point of Care Liver Disease Diagnostics (Phase 2) · recruiting
NCT06661655 — Evaluation of a New Ultrasound System for the Non-invasive Assessment of Liver Steatosis in MASLD/MASH Patients · NA · recruiting
NCT07093346 — The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patient · NA · recruiting
NCT06879236 — Secondary and Tertiary Digital Prevention of Non-alcoholic and Dysmetabolic Liver Disease · recruiting
NCT06888310 — Optimizing Noninvasive assessMent Of DysmEtabolic Compensated Advanced Liver Disease · NA · recruiting

Other Hvidovre University Hospital trials

Trials by the same sponsor.

NCT07561164 — Feasibility of a Co-designed Mobility Intervention After Hip Fracture Surgery · NA · not yet recruiting
NCT06909240 — Progressive Gait Training After First-time Deep Venous Thrombosis: Clinical Effectiveness and Involved Mecanisms (The DV · NA · recruiting
NCT07054216 — Probiotic for Infants · NA · recruiting
NCT07029334 — Effectiveness Evaluation of Social Prescribing · recruiting
NCT06789484 — Characterization of the Gastrointestinal Microbiota in Newborn Infants · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04581421 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Hvidovre University Hospital
Last refreshed: 23 January 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04581421.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing