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NCT04579172
Conservative Management of Morbidly Adherent Anterior Situated Placenta
NA trial testing Cervico- isthmic compression suture in Placenta Accreta in 40 participants. Completed in 1 November 2021.
1 October 2021
Quick facts
| Lead sponsor | Mansoura University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 40 |
| Start date | 30 September 2020 |
| Primary completion | 1 October 2021 |
| Estimated completion | 1 November 2021 |
| Sites | 1 location across Egypt |
Drugs / interventions tested
- Cervico- isthmic compression suture
- Anterior wall uterine resection:
Conditions studied
- Placenta Accreta — all drugs for Placenta Accreta →
Sponsor
Mansoura University Hospital
Who can join
Adults 18 to 40, female only, with Placenta Accreta. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Placenta accreta is defined as abnormal trophoblast invasion of part or the entire placenta into the myometrium of the uterine wall. Placenta accreta spectrum (PAS), formerly known as morbidly adherent placenta, refers to the range of pathologic adherence of the placenta, including placenta increta, percreta, and accreta. An important risk factor of placenta accreta is placenta previa in the presence of a uterine scar. Placenta previa is an independent risk factor for placenta accreta.Additional reported risk factors for placenta accreta include increased maternal age and multiparity, other prior uterine surgery, prior uterine curettage,uterine irradiation, Asherman syndrome, uterine leiomyomata, uterine anomalies, hypertensive disorders of pregnancy and smoking. (1,2) Maternal morbidity and mortality can occur because of severe and sometimes life-threatening hemorrhage, which often requires blood transfusion also and rates of maternal death are increased for women with PAS. Additionally, patients with PAS are more likely to require hysterectomy at the time of delivery or during the postpartum period and have longer hospital stays states.(3) According to FIGO Classification of PAS Disorders 2019 There are three grades. Grade 1: abnormally adherent placenta (placenta adherent or accreta) - attached directly to the surface of the middle layer of the uterine wall (myometrium) without invading it, Grade 2: abnormally invasive placenta (increta) - invasion into the myometrium and Grade 3: abnormally invasive placenta (percreta) invasion may reach surrounding pelvic tissues, vessels and organs.(4) Nowadays, fertility sparing and conservative methods can be applied. These methods include placenta left in situ, cervical inversion technique , triple-P procedure, cervico-isthmic compression suture and anterior wall uterine resection
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04579172
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Placenta Accreta
Currently open trials in the same condition.
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- NCT06465836 — Simplified Conservative Measures in Managing Morbidly Adherent Placenta in Beni-Suef University · NA · recruiting
- NCT06185894 — Single-step Placenta Accreta Resective Technique Tourniqueted vs Absence, Conservative Uterine Surgery · NA · recruiting
- NCT06833606 — Diagnosis and Outcomes of Placental Accretism · recruiting
- NCT05922397 — Placenta Accreta Spectrum Topographic Classification · recruiting
Other Mansoura University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04579172 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Mansoura University Hospital
- Last refreshed: 6 April 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04579172.
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