NCT04576637

Neurophysiological Monitoring and Videolaryngoscopy

Status unknown NA Last updated 3 May 2022

What this trial tests

NA trial testing Neurophysiological monitoring during intubation in Postsynaptic Potential Summation in 20 participants. Status unknown.

Timeline

21 October 2020

Primary endpoint
21 December 2022

21 February 2023

Quick facts

Lead sponsor	Rabin Medical Center
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	supportive care
Enrollment	20
Start date	21 October 2020
Primary completion	21 December 2022
Estimated completion	21 February 2023
Sites	1 location across Israel

Drugs / interventions tested

• Neurophysiological monitoring during intubation

Conditions studied

• Postsynaptic Potential Summation — all drugs for Postsynaptic Potential Summation →

Sponsor

Rabin Medical Center

Who can join

18 and older, any sex, with Postsynaptic Potential Summation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Myopathic patients undergoing cervical spine surgery are at risk for postoperative neurological deficits and sequelae.

Awake fiberoptic intubation is considered the technique of choice for tracheal intubation in patient with cervical spine instability. However, awake fiberoptic intubation frequently causes significant patient discomfort, requires patient cooperation, anesthesiologist expertise and the availability of costly equipment .

Videolaryngoscopy guided intubation is considered to be an effective alternative to awake fiberoptic intubation for cervical spine surgeries.

Intraoperative neurophysiological monitoring (IONM) is a method that provides real time evaluation of the functional integrity of neural structures. The goal of IONM is to make surgery safer by detecting incipient neurological insults at a time when it can be avoided or minimized and by aiding in the identification of neural structure Rayia, et al. have described a case of monitoring intubation and neck extension for the indication of thyroidectomy in a Down syndrome boy with atlantoaxial instability under anesthesia with propofol and remifentanil without neuromuscular blockade. The authors conclude that this approach can be used to protect against spinal cord compression.

While research has thoroughly evaluated the effect of laryngoscopy and intubation on cervical spine movement, to date, little is known about the impact of intubation process on neurophysiological responses, and on the feasibility of utilizing IONM for establishing a safe airway intubation.

This prospective, interventional, cohort study is the first, to our knowledge, to examine the feasibility and added benefits of IONM throughout anesthetic intubation in patients undergoing cervical spine surgeries with the use of videolarynscope guided intubation.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.