NCT04574388 (COLP) is a NA clinical trial of open label placebo in Spine Surgery, sponsored by Brigham and Women's Hospital.

Who is sponsoring NCT04574388?

NCT04574388 is sponsored by Brigham and Women's Hospital.

What drugs are being tested in NCT04574388?

Interventions in NCT04574388: open label placebo.

What condition does NCT04574388 study?

NCT04574388 studies Spine Surgery.

Is NCT04574388 still recruiting?

NCT04574388 is currently completed. Last updated 13 September 2021.

Last reviewed 2021-09-13 · How we verify

NCT04574388: COLP

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Evaluation of Open-Label Conditioned Placebo Analgesia for Postoperative Opioid Reduction Following Spinal Fusion

Completed NA Last updated 13 September 2021

What this trial tests

NA trial testing open label placebo in Spine Surgery in 51 participants. Completed in 10 March 2020.

Timeline

30 November 2018

Primary endpoint
10 March 2020

10 March 2020

Quick facts

Lead sponsor	Brigham and Women's Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	other
Enrollment	51
Start date	30 November 2018
Primary completion	10 March 2020
Estimated completion	10 March 2020
Sites	1 location across United States

Drugs / interventions tested

open label placebo — full drug profile →

Conditions studied

Spine Surgery — all drugs for Spine Surgery →

Sponsor

Brigham and Women's Hospital

Who can join

Adults 18 to 75, any sex, with Spine Surgery. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This research aims to understand the impact of conditioned open label placebo (COLP) on opioid consumption and pain after surgery. The hypothesis being tested is that by pairing a non-deceptive placebo pill with regularly prescribed pain killers after surgery, will allow reduction in opioids taken while maintaining the same level of analgesia.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Conditioned open-label placebo for opioid reduction after spine surgery: a randomized controlled trial.
Flowers KM, Patton ME, Hruschak VJ, Fields KG, et al · · 2021 · cited 35× · PMID 33449503 · DOI 10.1097/j.pain.0000000000002185

Verify or expand the search:

Other trials of open label placebo

Trials testing the same drug.

NCT04250571 — Taking Open Label Placebo Further: Trial of Imaginary Pills in Test Anxiety · NA · completed

Other recruiting trials for Spine Surgery

Currently open trials in the same condition.

NCT06827795 — An Open, Parallel-group, Randomized, Medical Device Study to Assess the Usability and Performance of Surgify HaloTM in S · NA · recruiting
NCT07344467 — Oral Melatonin Versus Oral Pregabalin on Postoperative Pain and Anxiety Following Spine Surgery · NA · recruiting
NCT06975072 — Effect of Magnesium on Neuromonitoring · Phase 4 · recruiting
NCT06785350 — Minimum Effective Dose of Incisional Local Infiltration Betamethasone for the Prevention of Pain After Spinal Surgery · NA · recruiting
NCT06439953 — Irrisept Solution for Instrumented Spine Surgery · NA · recruiting

Other Brigham and Women's Hospital trials

Trials by the same sponsor.

NCT07011758 — Dynamic Treatment Regimes for Opioid Use Disorder · Phase 2 · not yet recruiting
NCT06310018 — Augmented Ultrasound-Facilitated, Catheter-Directed Fibrinolysis for PE · suspended
NCT04519177 — Randomized Trial of a Sleep Disorders Program on Firefighter Safety and Disability ... · NA · not yet recruiting
NCT06355986 — Computerized Decision Support to Prevent Stroke in Atrial Fibrillation · NA · not yet recruiting
NCT06099275 — Evaluation of Hemodynamics in People With Untreated Preeclampsia Using Echocardiography · suspended

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04574388 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Brigham and Women's Hospital
Last refreshed: 13 September 2021

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04574388.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing