Last reviewed · How we verify
NCT04570618: ExPRESS
Early Prediction of Sepsis
NA trial testing Unblinded AlgoDx Sepsis Prediction Algorithm in Sepsis in 320 participants. Completed in 1 November 2021.
1 November 2021
Quick facts
| Lead sponsor | AlgoDx |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | diagnostic |
| Enrollment | 320 |
| Start date | 1 December 2020 |
| Primary completion | 1 November 2021 |
| Estimated completion | 1 November 2021 |
| Sites | 1 location across Sweden |
Drugs / interventions tested
- Unblinded AlgoDx Sepsis Prediction Algorithm
- Blinded AlgoDx Sepsis Prediction Algorithm
Conditions studied
- Sepsis — all drugs for Sepsis →
Sponsor
AlgoDx
Who can join
18 and older, any sex, with Sepsis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
In this clinical trial a novel Medical Device Software will be validated prospectively. The software incorporates a machine learning algorithm capable of predicting sepsis by using routine clinical variables in adult patients at Intensive Care Units.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
A Machine Learning Sepsis Prediction Algorithm for Intended Intensive Care Unit Use (NAVOY Sepsis): Proof-of-Concept Study.
Persson I, Östling A, Arlbrandt M, Söderberg J, et al · · 2021 · cited 20× · PMID 34591016 · DOI 10.2196/28000 -
The Potential Cost and Cost-Effectiveness Impact of Using a Machine Learning Algorithm for Early Detection of Sepsis in Intensive Care Units in Sweden.
Ericson O, Hjelmgren J, Sjövall F, Söderberg J, et al · · 2022 · cited 15× · PMID 35620451 · DOI 10.36469/jheor.2022.33951 -
Early Prediction of Sepsis in Intensive Care Patients Using the Machine Learning Algorithm NAVOY® Sepsis, a Prospective Randomized Clinical Validation Study
Persson I, Macura A, Becedas D, Sjövall F. · · 2023 · DOI 10.21203/rs.3.rs-2573595/v1
Verify or expand the search:
- PubMed search for NCT04570618
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Sepsis
Currently open trials in the same condition.
- NCT07507877 — Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness · recruiting
- NCT07154615 — Assessing Immune Dysfunction in Sepsis · recruiting
- NCT07419802 — OxiCLEAR (Oxiris Cytokines and Endotoxin Adsorption Rate) Study · recruiting
- NCT07351344 — African Survey on Sepsis Knowledge (ASK) · recruiting
- NCT07448805 — Accuracy and Safety of the Syai Tag System for Continuous Glucose Monitoring in Intensive Internal Care Unit · NA · recruiting
Other AlgoDx trials
Trials by the same sponsor.
- NCT05095220 — Integration of NAVOY® Sepsis in an Electronic Health Record System · completed
- NCT05424874 — Clinical Validation of NAVOY® Acute Kidney Injury in Swedish ICU Patients · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04570618 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by AlgoDx
- Last refreshed: 3 November 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04570618.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing