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NCT04566718
A Treatment Legacy Effect of Metformin in Obese Women With PCOS
trial testing Metformin in PCOS in 40 participants. Completed in 1 February 2020.
4 December 2019
Quick facts
| Lead sponsor | University Medical Centre Ljubljana |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 40 |
| Start date | 25 March 2019 |
| Primary completion | 4 December 2019 |
| Estimated completion | 1 February 2020 |
| Sites | 1 location across Slovenia |
Drugs / interventions tested
- Metformin (metformin) — full drug profile →
Conditions studied
- PCOS — all drugs for PCOS →
Sponsor
University Medical Centre Ljubljana
Who can join
Adults 18 to 55, female only, with PCOS. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Metformin has multiple health promoting effects and it may serve as a preventive measure for individuals who are at high risk for metabolic complications. According to the latest international guidelines it should be considered as an adjunct therapy to lifestyle intervention in all overweight/obese women with PCOS, independently of their glucose homeostasis and menstrual regularity. However, there is no clear answer for how long metformin should be prescribed in this subset of women with PCOS and for how long the beneficial impact would sustain after treatment cessation. The investigators compared the consequences of metformin withdrawal after long-term therapy as opposed to the consequences of metformin suspension after short term therapy in overweight/obese women with PCOS that had previously responded to metformin by means of moderate weight loss, improved menstrual frequency and sustained normal glucose homeostasis.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study.
Kravos NA, Janež A, Goričar K, Dolžan V, et al · · 2021 · cited 6× · PMID 33845893 · DOI 10.1186/s13098-021-00660-5
Verify or expand the search:
- PubMed search for NCT04566718
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other recruiting trials for PCOS
Currently open trials in the same condition.
- NCT06424860 — Fish Oil, Metformin and Heart Health in PCOS · Phase 1 · recruiting
- NCT06742710 — Liraglutide Treatment in Obese Infertile PCOS Women · Phase 4 · recruiting
- NCT07255911 — Cabergoline & Letrozole Versus Letrozole in Ovulation Induction in PCOS · NA · recruiting
- NCT06793072 — Adipokines in Polycystic Ovary Syndrome · recruiting
- NCT06591169 — Lifestyle Changes in PCOS with OSA and NAFLD · NA · recruiting
Other University Medical Centre Ljubljana trials
Trials by the same sponsor.
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- NCT07354880 — Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease · Phase 4 · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04566718 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Medical Centre Ljubljana
- Last refreshed: 5 November 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04566718.
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