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NCT04565886
Non-surgical Mechanical Therapy of Peri-implantitis With or Without Adjunctive Diode Laser Application
NA trial testing Diode laser application in Peri-Implantitis in 30 participants. Completed in 1 July 2022.
1 August 2021
Quick facts
| Lead sponsor | University of Bern |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 December 2019 |
| Primary completion | 1 August 2021 |
| Estimated completion | 1 July 2022 |
| Sites | 1 location across Switzerland |
Drugs / interventions tested
- Diode laser application
- Sham Diode laser
Conditions studied
- Peri-Implantitis — all drugs for Peri-Implantitis →
Sponsor
University of Bern
Who can join
18 and older, any sex, with Peri-Implantitis. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Peri-implantitis is a pathological condition occurring in tissues around dental implants, characterized by inflammation in the peri-implant connective tissue and progressive loss of supporting bone. The goals of peri-implantitis treatment is the resolution of peri-implant soft tissue inflammation and stabilization of the bony attachment (e.g., the level of osseointegration). For this decontamination of the implant surface is mandatory. In order to increase implant surface decontamination, several adjunctive tools have been proposed and investigated both in pre-clinical and clinical studies such as the use of photodynamic therapy and lasers. So far, no data are available to clearly demonstrate the efficacy of the adjunctive use of a diode laser in the non-surgical treatment of peri-implantitis. Therefore, the aim of the present randomized controlled trial (RCT) is to investigate the adjunctive effect of the application of a diode laser to treat peri-implantitis lesions by means of a non-surgical approach. A total of 30 patients is randomly allocated to two groups. The test group receives 3 x nonsurgical mechanical treatment with diode laser application whereas the control group receives the same treatment with sham laser application. The primary outcome is the peri-implant pocket probing depth at 12 months.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Non-surgical mechanical therapy of peri-implantitis with or without repeated adjunctive diode laser application. A 6-month double-blinded randomized clinical trial.
Roccuzzo A, Klossner S, Stähli A, Imber JC, et al · · 2022 · cited 38× · PMID 35775311 · DOI 10.1111/clr.13969
Verify or expand the search:
- PubMed search for NCT04565886
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Peri-Implantitis
Currently open trials in the same condition.
- NCT07012915 — Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis · NA · recruiting
- NCT06679283 — Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF) · NA · recruiting
- NCT06017817 — Antibacterial Photodynamic Therapy in the Management of Peri-implantitis · NA · recruiting
- NCT06364982 — Distance Between Dental Implants as a Risk Indicator for Peri-implant Disease. · recruiting
- NCT06288919 — Erythritol vs Ultrasonic Scaler Prophylaxis Systems on Dental Implants With Crowns Made by Different Materials · NA · active not recruiting
Other University of Bern trials
Trials by the same sponsor.
- NCT05940662 — Cost Effectiveness of Various Implant Placement Protocols in the Esthetic Zone · Phase 4 · suspended
- NCT02919163 — Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 6 of 7) · NA · not yet recruiting
- NCT02919189 — Systematically Assessing Effects of Colored Light on Humans With a Multi-modal Approach (Substudy 5 of 7) · NA · not yet recruiting
- NCT04817592 — Characterization of the Corneal Biomechanics of Patients Treated by Corneal Lenticule Extraction for Advanced Refractive · not yet recruiting
- NCT06806150 — The INSPIRE Study: INvestigation of Swiss Physicians Inner-life, Resilience, and Emotions · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04565886 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Bern
- Last refreshed: 9 August 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04565886.
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