NCT04564196

Breath Metabolomics in the Laboring Parturient

Terminated Last updated 8 June 2023

What this trial tests

trial testing Breath Sample in Labor Onset and Length Abnormalities in 53 participants. Terminated before completion.

Timeline

11 November 2020

Primary endpoint
6 June 2023

6 June 2023

Quick facts

Lead sponsor	Stanford University
Status	Terminated
Study type	OBSERVATIONAL
Enrollment	53
Start date	11 November 2020
Primary completion	6 June 2023
Estimated completion	6 June 2023
Sites	1 location across United States

Drugs / interventions tested

• Breath Sample

Conditions studied

• Labor Onset and Length Abnormalities — all drugs for Labor Onset and Length Abnormalities →

Sponsor

Stanford University

Who can join

18 and older, female only, with Labor Onset and Length Abnormalities. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is primarily a feasibility study to determine whether quantitative measurement of volatile organic compounds (VOCs) in the breath of parturients undergoing labor is possible.

Aim A: To determine baseline values of breath metabolites and volatile organic compounds (VOCs) in the breath for term pregnant women.

Aim B: To gather preliminary data to determine breath metabolite and volatile organic compound (VOCs) signature change during labor and delivery.

Aim C: Compare the breath metabolite and volatile organic compound (VOCs) signature women undergoing induction compared to spontaneous vaginal deliveries.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Quantification of breath metabolites in labouring versus non-labouring patients: a feasibility study.
   Hengelage J, Fowler C, Goldsberry MD, Stockert E, et al · · 2025 · PMID 40930875 · DOI 10.1016/j.bja.2025.07.081