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NCT04563078
Effect of TMS on PTSD Biomarkers
NA trial testing Transcranial Magnetic Stimulation (TMS) in Post Traumatic Stress Disorder in 63 participants. Completed in 28 September 2025.
28 March 2025
Quick facts
| Lead sponsor | Emory University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 63 |
| Start date | 15 February 2021 |
| Primary completion | 28 March 2025 |
| Estimated completion | 28 September 2025 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Transcranial Magnetic Stimulation (TMS)
- Sham Transcranial Magnetic Stimulation (TMS)
Conditions studied
- Post Traumatic Stress Disorder — all drugs for Post Traumatic Stress Disorder →
Sponsor
Emory University
Who can join
Adults 18 to 65, any sex, with Post Traumatic Stress Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The study will (1) assess feasibility of a TMS treatment in an underserved population; (2) determine if this TMS treatment protocol improves PTSD symptoms and biological markers of PTSD such as brain functioning and startle responses; (3) define new brain targets for future TMS studies; (4) provide the first data for individual differences, which will help personalize treatment for PTSD patients; (5) improve knowledge of the neurobiology of PTSD and treatment response.
Publications & conference data
6 peer-reviewed publications reference this trial (live from Europe PMC):
-
Defining focal brain stimulation targets for PTSD using neuroimaging.
van Rooij SJH, Sippel LM, McDonald WM, Holtzheimer PE. · · 2021 · cited 20× · PMID 33876868 · DOI 10.1002/da.23159 -
Repetitive transcranial magnetic stimulation for post-traumatic stress disorder in adults.
Brown R, Cherian K, Jones K, Wickham R, et al · · 2024 · cited 6× · PMID 39092744 · DOI 10.1002/14651858.cd015040.pub2 -
Interventional Psychiatry and Emerging Treatments for Posttraumatic Stress Disorder (PTSD): A Systematic Review.
Janssen-Aguilar R, Meshkat S, Al-Shamali HF, Perivolaris A, et al · · 2025 · cited 2× · PMID 40879152 · DOI 10.5152/pcp.2025.241027 -
Towards predicting posttraumatic stress symptom severity using portable EEG-derived biomarkers.
Peddi A, Sendi MSE, Minton ST, Langhinrichsen-Rohling R, et al · · 2025 · cited 2× · PMID 39948125 · DOI 10.1038/s41598-025-88426-1 -
Advancing TMS for PTSD - From networks to individuals.
Sompolpong P, van Rooij SJH. · · 2025 · cited 1× · PMID 41059079 · DOI 10.1016/j.transm.2025.100178 -
Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial.
van Rooij SJH, Langhinrichsen-Rohling R, Minton ST, Hinojosa CA, et al · · 2026 · PMID 41922982 · DOI 10.1176/appi.ajp.20250749
Verify or expand the search:
- PubMed search for NCT04563078
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other recruiting trials for Post Traumatic Stress Disorder
Currently open trials in the same condition.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04563078 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Emory University
- Last refreshed: 9 October 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04563078.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing