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NCT04558671: RESPIRE
Preschool Bronchial Remodeling and Risk of Exacerbation
trial testing asthma exacerbations in Preschool Severe Asthma in 56 participants. Completed in 24 September 2020.
24 September 2020
Quick facts
| Lead sponsor | University Hospital, Bordeaux |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 56 |
| Start date | 16 September 2020 |
| Primary completion | 24 September 2020 |
| Estimated completion | 24 September 2020 |
| Sites | 2 locations across France |
Drugs / interventions tested
- asthma exacerbations
Conditions studied
- Preschool Severe Asthma — all drugs for Preschool Severe Asthma →
Sponsor
University Hospital, Bordeaux
Who can join
Adults 1 to 5, any sex, with Preschool Severe Asthma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Bronchial remodeling is an abnormal tissue repair process of the bronchial wall components that characterizes severe asthma which can include epithelial abrasion, thickening of the reticular basement membrane (RBM), an increase in bronchial fibrosis, blood vessel count, mucosal gland mass and/or bronchial smooth muscle (BSM) mass. We identified using latent class analysis two classes of patients. Compared to the second class, the first class was characterized by an increase in RBM thickness, blood vessel count, BSM mass and a decrease in RBM-BSM distance, mucus gland mass and bronchial fibrosis. We then hypothesized that this first latent class identified children at risk of asthma exacerbations.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Bronchial Remodeling-based Latent Class Analysis Predicts Exacerbations in Severe Preschool Wheezers.
Fayon M, Beaufils F, Esteves P, Campagnac M, et al · · 2023 · cited 19× · PMID 36108144 · DOI 10.1164/rccm.202205-0913oc
Verify or expand the search:
- PubMed search for NCT04558671
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04558671 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bordeaux
- Last refreshed: 29 September 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04558671.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing