NCT04557592: CINERGY

Comparisons of gaIt aNalyses pERformance Between the Gaitrite walkwaYs

Completed Last updated 21 September 2020

What this trial tests

trial in Gait Apraxia in 98 participants. Completed in 26 February 2020.

Timeline

17 June 2019

Primary endpoint
26 February 2020

26 February 2020

Quick facts

Lead sponsor	University Hospital, Angers
Status	Completed
Study type	OBSERVATIONAL
Enrollment	98
Start date	17 June 2019
Primary completion	26 February 2020
Estimated completion	26 February 2020
Sites	1 location across France

Conditions studied

• Gait Apraxia — all drugs for Gait Apraxia →
• Alzheimer Disease — all drugs for Alzheimer Disease →
• Impaired Cognition — all drugs for Impaired Cognition →

Sponsor

University Hospital, Angers

Who can join

74 and older, any sex, with Gait Apraxia or Alzheimer Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The GAITRite® system is an instrumented with resistive pressure sensors gait analyzer. It was first validate in 2001 against paper-and-pencil (intraclass correlation coefficient \[ICC\] \> 95%) for spatial measures and against video-based (ICC \> 93%) for temporal measures, and was thus a reliable tools to measure step lengths and times in both walkway center and left-of-center measurements. It was considered as one of the gold standards in gait analyses. This gait analyze system may distinguish prospectively faller and non-faller older adults, but it can detect spatial, temporal, and spatiotemporal measures of gait and greater variability of gait parameters which were associated with and predictive of both global- and domain-specific cognitive decline. Moreover, spatiotemporal gait parameters analyzed using GAITRite® were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementia than in AD suggesting that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.

Nevertheless, GAITRite® is not a unique system and it comprises different walkways. One of these technologies was a roll-up system (platinum plus classic, RE, Basic and Safari), and the other was a system composed by a changeable association of plates (CIRFACE). In order to ensure a good comparability between studies using these different walkways, it appears important to compare the performances of these walkways in gait analysis. Thus, the main aim of this study was to compare the performances in gait analyze between the GAITRite® platinum plus classic and the GAITRite® CIRFACE among older adults. Secondary aims were to compare these parameters among patients with cognitive complaint, minor or major neurocognitive disorder (NCD) related to Alzheimer disease.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Comparison of spatio-temporal gait parameters between the GAITRite® platinum plus classic and the GAITRite® CIRFACE among older adults: a retrospective observational study.
   Sacco G, Ben-Sadoun G, Gautier J, Simon R, et al · · 2023 · cited 4× · PMID 36882705 · DOI 10.1186/s12877-023-03811-7