Last reviewed · How we verify
NCT04556929: EDGE
Enhanced Detection in Glioma Excision
NA trial testing Intra-operative imaging of 5-ALA fluorescence using ultra-high sensitivity camera in Glioma in 4 participants. Terminated before completion.
3 November 2021
Quick facts
| Lead sponsor | University of Oxford |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 4 |
| Start date | 21 September 2020 |
| Primary completion | 3 November 2021 |
| Estimated completion | 3 November 2021 |
| Sites | 1 location across United Kingdom |
Drugs / interventions tested
- Intra-operative imaging of 5-ALA fluorescence using ultra-high sensitivity camera
- Intra-operative imaging of 5-ALA fluorescence using in-built operative microscope camera
- Biopsies — full drug profile →
Conditions studied
- Glioma — all drugs for Glioma →
Sponsor
University of Oxford
Who can join
18 and older, any sex, with Glioma. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to determine whether use of an ultra-high sensitivity camera with enhanced imaging technology can be used during surgery to detect areas of brain tissue affected by diffuse glioma, a type of brain cancer.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Safe surgery for glioblastoma: Recent advances and modern challenges.
Gerritsen JKW, Broekman MLD, De Vleeschouwer S, Schucht P, et al · · 2022 · cited 59× · PMID 36127890 · DOI 10.1093/nop/npac019
Verify or expand the search:
- PubMed search for NCT04556929
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04556929 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Oxford
- Last refreshed: 22 March 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04556929.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing