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NCT04556032
Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women
NA trial testing L-Ergothioneine 10 mg/d in Healthy in 4 participants. Terminated before completion.
30 October 2020
Quick facts
| Lead sponsor | Midwest Center for Metabolic and Cardiovascular Research |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | supportive care |
| Enrollment | 4 |
| Start date | 9 September 2020 |
| Primary completion | 30 October 2020 |
| Estimated completion | 30 October 2020 |
| Sites | 1 location across United States |
Drugs / interventions tested
- L-Ergothioneine 10 mg/d
- L-Ergothioneine 25 mg/d
- Placebo
Conditions studied
- Healthy — all drugs for Healthy →
Sponsor
Midwest Center for Metabolic and Cardiovascular Research
Who can join
Adults 55 to 79, any sex, with Healthy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The objective of this study is to assess the effects of ergothioneine at two doses, compared to placebo, on cognition, mood, and sleep in healthy adult men and women.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Advances and prospects of ergothioneine in the treatment of cognitive frailty.
Gede AMMI, Gu Q, Phukhatmuen P, Xiong J, et al · · 2025 · PMID 40914903 · DOI 10.1080/07853890.2025.2555742
Verify or expand the search:
- PubMed search for NCT04556032
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Midwest Center for Metabolic and Cardiovascular Research trials
Trials by the same sponsor.
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- NCT06923332 — A Trial to Assess the Effects of Diets With and Without Inulin on Energy Expenditure in Adults. · NA · completed
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- NCT06269094 — A Study to Understand How Continuous Glucose Monitors Impact Eating Behavior · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04556032 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Midwest Center for Metabolic and Cardiovascular Research
- Last refreshed: 4 November 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04556032.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing