Last reviewed · How we verify
NCT04554212: BRAINS
Blood Flow Restriction Training After Patellar INStability
NA trial testing Blood Flow Restriction Training in Patellar Dislocation in 78 participants. Currently enrolling.
30 June 2026
Quick facts
| Lead sponsor | Caitlin Conley |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 78 |
| Start date | 9 September 2020 |
| Primary completion | 30 June 2026 |
| Estimated completion | 30 June 2026 |
| Sites | 4 locations across United States |
Drugs / interventions tested
- Blood Flow Restriction Training
- Sham Blood Flow Restriction Training
Conditions studied
- Patellar Dislocation — all drugs for Patellar Dislocation →
- Knee Injuries — all drugs for Knee Injuries →
- Leg Injury — all drugs for Leg Injury →
- Wounds and Injuries — all drugs for Wounds and Injuries →
Sponsor
Caitlin Conley
Who can join
Adults 14 to 40, any sex, with Patellar Dislocation or Knee Injuries. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This research study is designed to allow health care professionals and researchers to answer many questions about whether a new type of physical therapy called blood flow restriction training (called BFRT) will improve recovery for those with patellar instability.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Blood flow Restriction training After patellar INStability (BRAINS Trial).
Brightwell BD, Stone A, Li X, Hardy P, et al · · 2022 · cited 5× · PMID 35090543 · DOI 10.1186/s13063-022-06017-1
Verify or expand the search:
- PubMed search for NCT04554212
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Blood Flow Restriction Training
Trials testing the same drug.
- NCT07340385 — Physiological and Biochemical Responses to Blood Flow Restriction Training · recruiting
- NCT07140796 — Effects of Hip Blood Flow Restriction and Shockwave Therapy on Q-Angle and Plantar Pressure in Adults With Genu Varum · NA · not yet recruiting
- NCT06490692 — The Effect of Blood Flow Restriction Training on Tennis Elbow · NA · recruiting
- NCT06536777 — Effects of Ballistic Six Exercises With and Without Blood Flow Restriction in Cricket Players · NA · recruiting
- NCT06928181 — Effects of Passive Blood-Flow-Restriction on Muscle Atrophy and Pain After Elective Total Knee Arthroplasty · NA · completed
Other recruiting trials for Patellar Dislocation
Currently open trials in the same condition.
- NCT06086080 — Non-operative Treatment in First-time Patellar Dislocation · NA · recruiting
- NCT04607538 — The Faroese Knee Cohort: Etiology and Long-term Implications of Trochlear Dysplasia and Patellar Dislocations. · recruiting
- NCT04294199 — Effect of Early Range of Motion Following First Time Patellar Dislocation · NA · active not recruiting
- NCT05706363 — Comparison of Two Graft Choices in Mediale Patellofemoral Ligament Reconstruction (MPFL) · NA · active not recruiting
- NCT03076008 — The Impact of Tibial Tubercle-trochlear Groove Distance and Patellar Height on the Outcome of Isolated Medial Patellofem · active not recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04554212 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Caitlin Conley
- Last refreshed: 3 July 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04554212.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing