NCT04552522

Immunological Response After Shrimp Oral Immunotherapy Treatment

Completed NA Results posted Last updated 3 April 2026

What this trial tests

NA trial testing shrimp allergy with intend to eat shrimp in Allergy to Shrimp in 20 participants. Completed in 30 December 2024.

Timeline

28 August 2020

Primary endpoint
31 October 2024

30 December 2024

Quick facts

Lead sponsor	Mahidol University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	20
Start date	28 August 2020
Primary completion	31 October 2024
Estimated completion	30 December 2024
Sites	1 location across Thailand

Drugs / interventions tested

• shrimp allergy with intend to eat shrimp

Conditions studied

• Allergy to Shrimp — all drugs for Allergy to Shrimp →
• Immunotherapy — all drugs for Immunotherapy →

Sponsor

Mahidol University

Who can join

Adults 12 to 40, any sex, with Allergy to Shrimp or Immunotherapy. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Change in Eliciting Dose of Shrimp During Oral Food Challenge Primary · Baseline and 12 months

Change in the eliciting dose (ED) of shrimp protein during oral food challenge from baseline to 12 months in participants with shrimp allergy undergoing shrimp oral immunotherapy compared with avoidance.

Group	Value	95% CI
Shrimp Allergy With Intend to Eat Shrimp	3233	1400 – 9900
Shrimp Allergy With Avoid Shrimp	25	-50 – 200

Adverse events — posted to ClinicalTrials.gov

Time frame: from enrollment until end of 12 months. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

Shrimp Allergy With Intend to Eat Shrimp

Serious: 1/10 (10%)

Deaths: 0/10

Shrimp Allergy With Avoid Shrimp

Serious: 4/10 (40%)

Deaths: 0/10

Serious adverse events (1 terms)

Reaction	System	Shrimp Allergy With Intend…	Shrimp Allergy With Avoid …
anaphylaxis	Respiratory, thoracic and mediastinal disorders	—	—

Most-reported serious reactions: anaphylaxis.

Data from ClinicalTrials.gov NCT04552522 adverse events section.

Sponsor's own description

Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and immunoblot analysis in shrimp allergy patients after shrimp oral immunotherapy.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Advances in Shellfish Allergy Therapy: From Current Approaches to Future Strategies.
   Heidari S, Ruethers T, Karnaneedi S, Yin LWS, et al · · 2025 · cited 4× · PMID 40668267 · DOI 10.1007/s12016-025-09077-8