Last reviewed · How we verify
NCT04551729: FRESH-UP
Fluid Restriction in Heart Failure Versus Liberal Fluid Uptake
NA trial testing Lifestyle advice for liberal fluid intake in Heart Failure in 504 participants. Completed in 28 November 2024.
23 September 2024
Quick facts
| Lead sponsor | Radboud University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 504 |
| Start date | 21 April 2021 |
| Primary completion | 23 September 2024 |
| Estimated completion | 28 November 2024 |
| Sites | 8 locations across Netherlands |
Drugs / interventions tested
- Lifestyle advice for liberal fluid intake
Conditions studied
- Heart Failure — all drugs for Heart Failure →
Sponsor
Radboud University Medical Center
Who can join
18 and older, any sex, with Heart Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Multi-centre open-label 1:1 randomized clinical trial in chronic heart failure patients on the effect of fluid restriction versus liberal fluid intake on quality of life.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial.
Herrmann JJ, Brunner-La Rocca HP, Baltussen LEHJM, Beckers-Wesche F, et al · · 2025 · cited 16× · PMID 40159556 · DOI 10.1038/s41591-025-03628-4 -
Fluid REStriction in Heart Failure vs Liberal Fluid UPtake: Rationale and Design of the Randomized FRESH-UP Study.
Herrmann JJ, Beckers-Wesche F, Baltussen LEHJM, Verdijk MHI, et al · · 2022 · cited 16× · PMID 35705150 · DOI 10.1016/j.cardfail.2022.05.015 -
Fluid Restriction for Patients with Heart Failure: Current Evidence and Future Perspectives.
Kato NP, Nagatomo Y, Kawai F, Kitai T, et al · · 2024 · cited 7× · PMID 39063995 · DOI 10.3390/jpm14070741
Verify or expand the search:
- PubMed search for NCT04551729
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Heart Failure
Currently open trials in the same condition.
- NCT06118983 — Improving TRansitions ANd OutcomeS for Heart FailurE Patients in Home Health CaRe (I-TRANSFER-HF) · NA · recruiting
- NCT07496372 — Efficacy and Safety of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Injection (HiCM-188) in Advanced Heart · Phase 3 · recruiting
- NCT07527156 — Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure · Phase 4 · recruiting
- NCT07263035 — Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure · Phase 4 · recruiting
- NCT07531966 — Vascular Complications After Kidney Transplantation · recruiting
Other Radboud University Medical Center trials
Trials by the same sponsor.
- NCT07485569 — Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial · Phase 1 · not yet recruiting
- NCT07514325 — MR-guided Adaptive Stereotactic Radiotherapy for Endometrial Cancer · NA · not yet recruiting
- NCT07530263 — Deposition of Inhaled Liposomal Amphotericin B in Chronic Pulmonary Aspergillosis (CPA) · Phase 1 · not yet recruiting
- NCT07532577 — Intranasal Insulin to Prevent Intensive Care Unit Delirium · Phase 2, PHASE3 · not yet recruiting
- NCT07504172 — Real-world Effectiveness and Dosing Patterns of Tirzepatide in People With Obesity · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04551729 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Radboud University Medical Center
- Last refreshed: 18 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04551729.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing