Who is sponsoring STIM_Bowel?

STIM_Bowel is sponsored by Oregon Health and Science University.

What condition does STIM_Bowel study?

STIM_Bowel studies Bowel Dysfunction, Postoperative Complications, Neuromuscular Blockade.

What drugs are being tested in STIM_Bowel?

Interventions: Sugammadex, Neostigmine.

What is the status of STIM_Bowel?

STIM_Bowel is currently COMPLETED.

Last reviewed 2024-07-29 · How we verify

Sugammadex To IMprove Bowel Function (STIM_Bowel)

NCT04546672 PHASE4 COMPLETED Results posted

Colon and rectal surgery is associated with high cost, long length of stay, high postoperative surgical site infection rate, high incidence of postoperative nausea and vomiting, and a high rate of hospital readmission. Return of bowel function is of utmost importance in avoiding patient discomfort, morbidity, and mortality after colorectal surgery. All patient having colorectal surgery receive neuromuscular paralysis, which is reversed at the end of surgery with either glycopyrrolate and neostigmine, or sugammadex. Glycopyrrolate and neostigmine both affect bowel function. Sugammadex has no effect on bowel function. The purpose of this study is to determine if a strategy of neuromuscular reversal with sugammadex, instead of glycopyrrolate and neostigmine, may increase gastric emptying after surgery and lead to less postoperative complications.

Details

Lead sponsor	Oregon Health and Science University
Phase	PHASE4
Status	COMPLETED
Enrolment	120
Start date	Tue Mar 16 2021 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Sun Aug 13 2023 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

Bowel Dysfunction
Postoperative Complications
Neuromuscular Blockade

Interventions

Sugammadex
Neostigmine

Countries

United States