NCT04545892 is a Phase 1 clinical trial of Capsaicin in Stroke, sponsored by Juan Manuel Marquez Romero.

Who is sponsoring NCT04545892?

NCT04545892 is sponsored by Juan Manuel Marquez Romero.

What drugs are being tested in NCT04545892?

Interventions in NCT04545892: Capsaicin.

Is NCT04545892 still recruiting?

NCT04545892 is currently completed. Last updated 11 September 2020.

Last reviewed 2020-09-11 · How we verify

NCT04545892

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Capsaicin for Cerebral Perfusion Augmentation.

Completed Phase 1 Last updated 11 September 2020

What this trial tests

Phase 1 trial testing Capsaicin in Stroke in 30 participants. Completed in 31 July 2020.

Timeline

1 December 2019

Primary endpoint
31 July 2020

31 July 2020

Quick facts

Lead sponsor	Juan Manuel Marquez Romero
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	30
Start date	1 December 2019
Primary completion	31 July 2020
Estimated completion	31 July 2020
Sites	1 location across Mexico

Drugs / interventions tested

Capsaicin (CAPSAICIN) — full drug profile →

Conditions studied

Stroke — all drugs for Stroke →

Sponsor

Juan Manuel Marquez Romero

Who can join

18 and older, any sex, with Stroke. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To determine the safety and effect of crescent doses of capsaicin upon serial transcranial Doppler (TCD) markers of cerebral blood flow (CBF). Methods We performed serial TCD testing in 30 healthy volunteers divided into five equal groups. Capsaicin doses ranged from 33 to 165 μMol. We recorded peak systolic and end-diastolic velocities in the middle cerebral artery (MCA), arterial pressure, and perceived pungency (PP) in five minutes intervals up to 20 minutes. We then calculated the mean velocity (MV), the pulsatility index (PI), and the CBF index.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Dose Escalation and Safety of Capsaicin for Cerebral Perfusion Augmentation: A Pilot Study.
Marquez-Romero JM, Huerta-Franco MR, Vargas-Luna M, Madrigal-Gutiérrez CA, et al · · 2021 · cited 7× · PMID 33966493 · DOI 10.1161/strokeaha.120.032773

Verify or expand the search:

Other trials of Capsaicin

Trials testing the same drug.

NCT07237022 — The Role of TRP Channels in DPN · recruiting
NCT06809569 — A Study to Evaluate Laser Speckle Contrast Imaging to Assess Changes in Chemical Agent-Induced Skin Blood Flow in Health · Phase 1 · completed
NCT05958173 — Effects of 6-month of Treatment With TRPV1 and TRPA1 Agonists in Older Patients With OD · NA · unknown
NCT05983263 — Analgesic Efficacy of Capsaicin 8% Patch (QUTENZA®) in Coccygodygnia · unknown
NCT05543837 — Capsaicin for Cerebral Perfusion Augmentation · Phase 2 · completed

Other recruiting trials for Stroke

Currently open trials in the same condition.

NCT06615973 — Screening for Social Determinants of Health (SDOH) and Cognitive Function in Individuals With History of Stroke · recruiting
NCT07494890 — Measurement Properties of Mechanical Cost of Walking for Individuals With Walking Impairment · NA · recruiting
NCT07356011 — Exoskeleton for Balance · NA · recruiting
NCT07523503 — Unilateral Versus Bilateral Task-specific Training on Motor Impairment, Upper Extremity Function, and Hand Dexterity in · NA · recruiting
NCT06704074 — Virtual Reality Task Oriented Training on Upper Limb Function in Stroke Patients · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04545892 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Juan Manuel Marquez Romero
Last refreshed: 11 September 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04545892.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing