NCT04544514

Earliest Lung Ultrasound Time for Predicting the Need of Surfactant

Completed Last updated 11 September 2020

What this trial tests

trial testing lung ultrasound in Respiratory Distress Syndrome in 71 participants. Completed in 31 December 2019.

Timeline

1 January 2017

Primary endpoint
31 December 2019

31 December 2019

Quick facts

Lead sponsor	Gozdem Kayki
Status	Completed
Study type	OBSERVATIONAL
Enrollment	71
Start date	1 January 2017
Primary completion	31 December 2019
Estimated completion	31 December 2019

Drugs / interventions tested

• lung ultrasound

Conditions studied

• Respiratory Distress Syndrome — all drugs for Respiratory Distress Syndrome →

Sponsor

Gozdem Kayki

Who can join

Adults 30 Minutes to 6 Hours, any sex, with Respiratory Distress Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Lung ultrasonography (LUS) is fast and easy technique. it also has high reliability, so it has started to be used more in evaluating respiratory distress in the neonatal period. The most important feature of LUS is being radiation-free. Three LUS findings that show respiratory distress syndrome were described. They were white lung appearance, lack of preserved areas and loss of pleural integrity. The sensitivity of these findings was found to be 98-100% and the specificity 92-100%. A few studies have shown that surfactant need can be determined by LUS.

It was observed that lung findings were more severe in LUS performed in the early period because of non-completed fetal lung fluid clearence, but the findings could be improved during follow-up. Therefore, it is not known when the earliest time of LUS shows the actual clinical condition and course of the patient.

This study was planned to find the most reliable and earliest US time. Evaluation with LUS was done at 30 minutes and repeated at 1, 2, 4 and 6 hours of life. The LUS findings would be compared with x-ray findings and the correlation of surfactant need with LUS findings would also be investigated.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Lung ultrasound (LUS) and surfactant treatment: looking for the best predictive moment.
   Kayki G, Yigit S, Tandircioglu UA, Celik HT, et al · · 2021 · cited 5× · PMID 33758395 · DOI 10.1038/s41372-021-01039-0