NCT04544306 is a NA clinical trial of Partial oral antimicrobial therapy in Infective Endocarditis, sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's.

What drugs are being tested in NCT04544306?

Interventions in NCT04544306: Partial oral antimicrobial therapy.

What condition does NCT04544306 study?

NCT04544306 studies Infective Endocarditis.

Is NCT04544306 still recruiting?

NCT04544306 is currently status unknown. Last updated 26 February 2024.

Last reviewed 2024-02-26 · How we verify

NCT04544306

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Partial Oral Antimicrobials to Treat Infective Endocarditis in People Who Inject Drugs

Status unknown NA Last updated 26 February 2024

What this trial tests

NA trial testing Partial oral antimicrobial therapy in Infective Endocarditis in 50 participants. Status unknown.

Timeline

1 June 2021

Primary endpoint
30 December 2024

30 June 2025

Quick facts

Lead sponsor	London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	50
Start date	1 June 2021
Primary completion	30 December 2024
Estimated completion	30 June 2025
Sites	2 locations across Canada

Drugs / interventions tested

Partial oral antimicrobial therapy

Conditions studied

Infective Endocarditis — all drugs for Infective Endocarditis →

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Who can join

Adults 18 to 75, any sex, with Infective Endocarditis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Infective endocarditis (IE) is a serious infection associated with significant morbidity and mortality. Recent studies demonstrated an increased risk of infective endocarditis in people who inject drugs (PWIDs). PWIDs have a high rate of non-compliance with hospital admissions and leaving against medical advice. A recent landmark randomized controlled trial demonstrated similar outcomes when comparing partial oral antimicrobial therapy to continued intravenous antimicrobial therapy in the general population. Performing a trial to explore the non-inferiority of oral compared to intravenous antimicrobial therapy in PWIDs is essential in advancing patient care in this high risk increasing population.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Review of management priorities for invasive infections in people who inject drugs: highlighting the need for patient-centred multidisciplinary care.
Attwood LO, McKechnie M, Vujovic O, Higgs P, et al · · 2022 · cited 12× · PMID 35754144 · DOI 10.5694/mja2.51623
Oral Antibiotics for Bacteremia and Infective Endocarditis: Current Evidence and Future Perspectives.
Eleftheriotis G, Marangos M, Lagadinou M, Bhagani S, et al · · 2023 · cited 4× · PMID 38138148 · DOI 10.3390/microorganisms11123004

Verify or expand the search:

Other recruiting trials for Infective Endocarditis

Currently open trials in the same condition.

NCT06269679 — CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis. · NA · recruiting
NCT05965362 — Prognosis of Patients With Infective Endocarditis and Risk Stratification Value of Biomarkers (ENDEAVOR） · recruiting
NCT06418048 — INfectious DIsease REgistry BIObank · recruiting
NCT07156292 — The Epidemiology Change From 2006 to 2022 of Infective Endocarditis in Taiwan · active not recruiting
NCT06309680 — Accuracy of Metagenomic Blood Sampling to Identify Pathogen in Infective Endocarditis Patients · active not recruiting

Other London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's trials

Trials by the same sponsor.

NCT07588711 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Neuropathic Pain Following Spinal Cord Injury · NA · not yet recruiting
NCT07585292 — Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy · NA · not yet recruiting
NCT07510906 — Evaluation of a Prostate-Targeted PET Imaging System (P-PET) for Detecting Prostate Cancer · NA · not yet recruiting
NCT03166072 — Health Education vs Meditation in Irreversible Age-Related Vision Loss Patients and Their Caregivers · NA · not yet recruiting
NCT06035809 — Sensory Motor Arousal Regulation Treatment (SMART) Study · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04544306 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Last refreshed: 26 February 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04544306.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing