Who is sponsoring NCT04542746?

NCT04542746 is sponsored by Iorio Research and Dental Practice.

What drugs are being tested in NCT04542746?

Interventions in NCT04542746: Minimally invasive surgical technique.

What condition does NCT04542746 study?

NCT04542746 studies Periodontal Pocket.

Is NCT04542746 still recruiting?

NCT04542746 is currently completed. Last updated 9 September 2020.

Last reviewed 2020-09-09 · How we verify

NCT04542746

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Treatment of Periodontal Intraosseous Defects

Completed NA Last updated 9 September 2020

What this trial tests

NA trial testing Minimally invasive surgical technique in Periodontal Pocket in 40 participants. Completed in 18 December 2018.

Timeline

28 July 2017

Primary endpoint
12 August 2018

18 December 2018

Quick facts

Lead sponsor	Iorio Research and Dental Practice
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	treatment
Enrollment	40
Start date	28 July 2017
Primary completion	12 August 2018
Estimated completion	18 December 2018
Sites	1 location across Italy

Drugs / interventions tested

Minimally invasive surgical technique

Conditions studied

Periodontal Pocket — all drugs for Periodontal Pocket →

Sponsor

Iorio Research and Dental Practice

Who can join

Adults 18 to 70, any sex, with Periodontal Pocket. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The aim of the present study was to evaluate the impact of surgical flap design on the healing of intrabony defects treated by means periodontal regeneration. Forty patients were enrolled and allocated random in two groups. Patients of test group received a minimally invasive surgical flap , while patients of control group received a conventional access flap. In both group the intrabony were treated by means the same periodontal regeneration procedure (i.e application of enamel matrix derivative). Periodontal parameters were recoded at baseline and after 12-months observation time.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

The role of surgical flap design (minimally invasive flap vs. extended flap with papilla preservation) on the healing of intrabony defects treated with an enamel matrix derivative: a 12-month two-center randomized controlled clinical trial.
Windisch P, Iorio-Siciliano V, Palkovics D, Ramaglia L, et al · · 2022 · cited 20× · PMID 34491446 · DOI 10.1007/s00784-021-04155-5

Verify or expand the search:

Other trials of Minimally invasive surgical technique

Trials testing the same drug.

NCT06428149 — Three Types of Papilla Incision in Periodontal Surgery · NA · recruiting

Other recruiting trials for Periodontal Pocket

Currently open trials in the same condition.

NCT07375004 — Injectable PRF in Non-Surgical Periodontal Treatment · NA · active not recruiting
NCT06522438 — Hyaluronic Acid and Octenidine Gel as an Adjunct to Non-surgical Periodontal Treatment · NA · recruiting
NCT06123000 — Modified Widman Flap vs Fibre Retention Osseous Resective Surgery · NA · recruiting
NCT06982248 — The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment · Phase 2 · active not recruiting
NCT06351982 — Treatment Of Shallow Periodontal Pockets 4-6mm Using AIRFLOW Prophylaxis Master Device With Erythritol vs Manual Scalers · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04542746 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Iorio Research and Dental Practice
Last refreshed: 9 September 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04542746.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing