Who is sponsoring NCT04542096?

NCT04542096 is sponsored by Vilnius University.

What drugs are being tested in NCT04542096?

Interventions in NCT04542096: Lung electrical impedance tomography monitoring.

What condition does NCT04542096 study?

NCT04542096 studies RDS - Infants, RDS of Prematurity, Respiratory Failure, Prematurity, Very Low Birth Weight Infant.

Is NCT04542096 still recruiting?

NCT04542096 is currently completed. Last updated 28 March 2025.

Last reviewed 2025-03-28 · How we verify

NCT04542096

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Real Time Evaluation of Dynamic Changes of the Lungs During Respiratory Support of VLBW Neonates Using EIT

Completed Last updated 28 March 2025

What this trial tests

trial testing Lung electrical impedance tomography monitoring in RDS - Infants in 72 participants. Completed in 20 May 2024.

Timeline

29 September 2020

Primary endpoint
20 April 2024

20 May 2024

Quick facts

Lead sponsor	Vilnius University
Status	Completed
Study type	OBSERVATIONAL
Enrollment	72
Start date	29 September 2020
Primary completion	20 April 2024
Estimated completion	20 May 2024
Sites	1 location across Lithuania

Drugs / interventions tested

Lung electrical impedance tomography monitoring

Conditions studied

RDS - Infants — all drugs for RDS - Infants →
RDS of Prematurity — all drugs for RDS of Prematurity →
Respiratory Failure — all drugs for Respiratory Failure →
Prematurity — all drugs for Prematurity →

Sponsor

Vilnius University

Who can join

Adults 22 Weeks to 36 Weeks, any sex, with RDS - Infants or RDS of Prematurity. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Electric Impedance Tomography (EIT) is a lung monitoring technique based on the injection of small currents and voltage measurements using electrodes on the skin surface generating cross-sectional images representing impedance change in a slice of the thorax. It is a real time, radiation free, non-invasive and portable. Neonatal respiratory distress syndrome (RDS) is a respiratory disorder resulting from immaturity of the lung structure and lack of surfactant. It is one the most common conditions in premature infants. Many of these infants require either invasive or non-invasive respiratory support. The goal of the study is to investigate the dynamic changes in pulmonary aeration during assisted breathing in very low birthweight preterm infants using pulmonary electrical impedance tomography. Currently most widely used methods to assess respiratory lung function are either invasive and/or indirect (ABG, pulse oximetry, transcutaneous pCO2 measurement), lacks temporal resolution (lung ultrasound) or emit ionizing radiation (CT). EIT provides information on regional lung aeration without the aforementioned shortcomings.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Noninvasive Respiratory Support Effects on Sighs in Preterm Infants by Electrical Impedance Tomography.
Virsilas E, Liubsys A, Janulionis A, Valiulis A. · · 2023 · cited 4× · PMID 36539568 · DOI 10.1007/s12098-022-04413-8
Respiratory Support Effects over Time on Regional Lung Ventilation Assessed by Electrical Impedance Tomography in Premature Infants.
Virsilas E, Valiulis A, Kubilius R, Peciuliene S, et al · · 2024 · cited 2× · PMID 38541220 · DOI 10.3390/medicina60030494
Short-Term Effects over Time of Endotracheal Suctioning on Very Low Birth Weight Premature Infants with RDS.
Virsilas E, Valiulis A, Liubsys A. · · 2025 · PMID 40723001 · DOI 10.3390/children12070808

Verify or expand the search:

Other Vilnius University trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04542096 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vilnius University
Last refreshed: 28 March 2025

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04542096.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing