Who is sponsoring NCT04538079?

NCT04538079 is sponsored by University College Cork.

What drugs are being tested in NCT04538079?

Interventions in NCT04538079: Multimodal objective non-invasive Monitoring.

What condition does NCT04538079 study?

NCT04538079 studies Hypotension and Shock, Hypoperfusion, Hemodynamic Instability, Intraventricular Hemorrhage, Cardiac Function, Circulatory Transition.

Is NCT04538079 still recruiting?

NCT04538079 is currently terminated. Last updated 27 January 2023.

Last reviewed 2023-01-27 · How we verify

NCT04538079: NOAH

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Non-invasive Objective Assessment of Hemodynamics in Preterm Neonates

Terminated Last updated 27 January 2023

What this trial tests

trial testing Multimodal objective non-invasive Monitoring in Hypotension and Shock in 56 participants. Terminated before completion.

Timeline

9 November 2019

Primary endpoint
31 May 2021

31 May 2021

Quick facts

Lead sponsor	University College Cork
Status	Terminated
Study type	OBSERVATIONAL
Enrollment	56
Start date	9 November 2019
Primary completion	31 May 2021
Estimated completion	31 May 2021
Sites	1 location across Ireland

Drugs / interventions tested

Multimodal objective non-invasive Monitoring

Conditions studied

Hypotension and Shock — all drugs for Hypotension and Shock →
Hypoperfusion — all drugs for Hypoperfusion →
Hemodynamic Instability — all drugs for Hemodynamic Instability →
Intraventricular Hemorrhage — all drugs for Intraventricular Hemorrhage →

Sponsor

University College Cork

Who can join

Adults 1 Minute to 20 Hours, any sex, with Hypotension and Shock or Hypoperfusion. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Study type: Prospective Observational trial Study design: Longitudinal Population: Preterm newborns \<32 weeks gestational age Hypothesis: The inclusion of non-invasive physiological measures of cardiac output, peripheral perfusion and brain oxygenation (NIRS) for preterm neonates is feasible and reveals additional information on the hemodynamic status compared to blood pressure alone. These measurements can improve the ability to rapidly identify those infants who might benefit from intervention and are correlated with short term clinical outcomes.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Non-invasive Cardiac Output Monitoring in Neonates.
O'Neill R, Dempsey EM, Garvey AA, Schwarz CE. · · 2020 · cited 23× · PMID 33585366 · DOI 10.3389/fped.2020.614585
Electrical Cardiometry during transition and short-term outcome in very preterm infants: a prospective observational study.
Schwarz CE, O'Toole JM, Healy DB, Panaviene J, et al · · 2024 · cited 5× · PMID 38189914 · DOI 10.1007/s00431-023-05387-1
iGenSig-Rx: an integral genomic signature based white-box tool for modeling cancer therapeutic responses using multi-omics data.
Lee S, Sun M, Hu Y, Wang Y, et al · · 2024 · PMID 38898383 · DOI 10.1186/s12859-024-05835-1

Verify or expand the search:

Other recruiting trials for Hypotension and Shock

Currently open trials in the same condition.

NCT07322133 — Dopamine vs. Norepinephrine for Hypotension in Neonates With Pulmonary Hypertension (DONE) · Phase 4 · recruiting
NCT07022847 — Pleth Variability Index for Predicting Low Blood Pressure During Maintenance Hemodialysis · recruiting
NCT05931601 — Early Initiated Vasopressor Therapy in the Emergency Department · Phase 3 · recruiting
NCT04760977 — Prehospital Management of Hypotensive Trauma in HEMS · recruiting

Other University College Cork trials

Trials by the same sponsor.

NCT07481240 — A Household-Based Dietary Intervention Study of Vitamin D Fortified Bread in Irish Families · NA · recruiting
NCT06857539 — Assessing Intellectual and Motor Outcomes in High-risk Infants · not yet recruiting
NCT07363928 — A Digital Cognitive Behavioural Therapy for Insomnia Intervention in Mild Cognitive Impairment and Mild Dementia · NA · completed
NCT06705582 — OASIS Study: Vitamin D Deficiency Prevention Among Older Adults in Ireland · NA · completed
NCT06709209 — AI-driven Narrow-band Imaging Score for Disease Assessment and Outcome Prediction in Ulcerative Colitis · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04538079 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University College Cork
Last refreshed: 27 January 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04538079.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing