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NCT04533698: Volu-CABG
Impact of Fluid Resuscitation Protocol on the Incidence of Reoperation for Bleeding After Emergency Cardiopulmonary Bypass Grafting
trial testing Assessment of reason for resternotomy in Resternotomy in 265 participants. Completed in 30 June 2024.
31 May 2021
Quick facts
| Lead sponsor | University Hospital, Basel, Switzerland |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 265 |
| Start date | 1 January 2009 |
| Primary completion | 31 May 2021 |
| Estimated completion | 30 June 2024 |
Drugs / interventions tested
- Assessment of reason for resternotomy
- Assessment of reason for avoidance of resternotomy
Conditions studied
- Resternotomy — all drugs for Resternotomy →
Sponsor
University Hospital, Basel, Switzerland
Who can join
Adults 18 to 99, any sex, with Resternotomy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This is a retrospective data analysis of patients that underwent elective or emergency cardiopulmonary bypass. Resternotomy due to bleeding is frequent after sternotomy. Also due to implementation of Argipressin into clinical practice fluid resuscitation protocol has changed to more vasopressors and less fluid within the past five years. The investigators want to explore the influence of volume resuscitation protocol on incidence of rethoracotomy during the past twenty years.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Conservative fluid resuscitation protocol does not reduce the incidence of reoperation for bleeding after emergency CABG.
Bruno J, Varayath M, Gahl B, Miazza J, et al · · 2024 · PMID 39251616 · DOI 10.1038/s41598-024-71028-8 -
Conservative Fluid Resuscitation Protocol Does Not Reduce the Incidence of Reoperation for Bleeding during the First 48 Hours after Emergency CABG
Bruno J, Varayath M, Gahl B, Miazza J, et al · · 2023 · DOI 10.21203/rs.3.rs-3503381/v1
Verify or expand the search:
- PubMed search for NCT04533698
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04533698 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Basel, Switzerland
- Last refreshed: 4 April 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04533698.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing