Last reviewed · How we verify

NCT04529629

Precise Diagnosis, Treatment and Prognostic Evaluation of Complicated Adrenal Tumor Diseases

Recruiting now Last updated 27 December 2021
What this trial tests

trial testing surgery or drug in Complicated Adrenal Tumor Diseases in 1,000 participants. Currently enrolling.

Timeline
30 August 2021
Primary endpoint
30 August 2040
30 August 2041

Quick facts

Lead sponsorShanghai Jiao Tong University School of Medicine
StatusRecruiting now
Study typeOBSERVATIONAL
Enrollment1,000
Start date30 August 2021
Primary completion30 August 2040
Estimated completion30 August 2041
Sites1 location across China

Drugs / interventions tested

Conditions studied

Sponsor

Shanghai Jiao Tong University School of Medicine

Who can join

Adults 18 to 75, any sex, with Complicated Adrenal Tumor Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The adrenal gland is an important organ that produces life hormones. There are many types of adrenal tumors, which tend to occur in young adults and affect the whole body. It has the dual threat: hormone secretion and tumor metastasis. At present, there are four major dilemmas in the clinical diagnosis and treatment of adrenal tumors: 1) Pulse secretion of the hormones, which are affected by many factors; and the diagnostic value of single hormone is limited; 2) Traditional imaging cannot accurately reflect the characteristics of hormone secretion. The prognosis cannot be accurately predicted; 3) The molecular characteristics of tumor cells and the microenvironment are unclear, making it difficult to implement early diagnosis and precise treatment; 4) Traditional pathology cannot determine the nature and long-term prognosis of the tumor, which makes the treatment delay, and the disease prognosis is extremely poor. It threatens the lives of patients. Starting from solving the above-mentioned key problems in the early stage, the research team has systematically established new clinical diagnostic technologies, hormone dynamic tests to accurately assess hormone secretion and segmented blood collection hormone determination technologies to accurately locate adrenal tumors; A series of important research results have been published in Science, Lancet Diabetes \& Endocrinology, Cell Research, etc To sum up, the goal of this research is improving the early diagnosis rate of complicated adrenal tumors especially in malignant tumors, developing the optimal treatment plan, avoiding unnecessary surgical treatment, improving the quality of life of patients, reducing mortality. This project will further integrate the adrenal cortex and medulla hormone mass spectrometry detection and the molecular markers of adrenal tumors through phenotypic, functional imaging, and molecular pathological evaluations, and built a sensitive drug screening platform that integrates visual drug response and molecular characteristics, thereby achieving precise diagnosis and treatment of complicated adrenal tumors.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other Shanghai Jiao Tong University School of Medicine trials

Trials by the same sponsor.

Verify against primary sources

Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04529629.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing