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NCT04529304
EEG-based Depth of Anesthesia-monitoring, Effects on Dosage and Cognition
NA trial testing Bilateral Bispectral Index and EEG in Postoperative Complications in 100 participants. Completed in 13 March 2026.
12 March 2026
Quick facts
| Lead sponsor | Oslo University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | other |
| Enrollment | 100 |
| Start date | 8 January 2021 |
| Primary completion | 12 March 2026 |
| Estimated completion | 13 March 2026 |
| Sites | 1 location across Norway |
Drugs / interventions tested
- Bilateral Bispectral Index and EEG
Conditions studied
- Postoperative Complications — all drugs for Postoperative Complications →
- Delayed Emergence From Anesthesia — all drugs for Delayed Emergence From Anesthesia →
- Cognitive Dysfunction — all drugs for Cognitive Dysfunction →
Sponsor
Oslo University Hospital
Who can join
Adults 18 to 85, any sex, with Postoperative Complications or Delayed Emergence From Anesthesia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Depth of anesthesia-monitoring based on EEG changes demands knowledge about the effects of the different anesthetic medications on EEG waveforms. The investigators want to investigate the use of the raw-EEG waveform in addition to indexes (BIS) and EEG spectrogram analyses for depth of anesthesia monitoring. The investigators hypothesize that with the use of this monitoring, anaesthesia providers will be able to better individualize the dosage of anesthetic drugs, and that this will reduce the total consumption of anesthetic medication , thus reducing time to wake-up after surgery. Some studies have indicated that too deep anesthesia, confirmed by "burst-suppression" or isoelectric-EEG , is associated with increased postoperative cognitive dysfunction (POCD). The investigators will therefore assess the patients with the Cambridge Neuropsychological Test Automated Battery tests in mild cognitive impairment (CANTAB-MCI) cognitive function assessment tool.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04529304
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Oslo University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04529304 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Oslo University Hospital
- Last refreshed: 16 March 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04529304.
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