Who is sponsoring NCT04527640?

NCT04527640 is sponsored by Indonesia University.

What condition does NCT04527640 study?

NCT04527640 studies Constipation, End Stage Renal Disease on Dialysis.

Is NCT04527640 still recruiting?

NCT04527640 is currently status unknown. Last updated 28 August 2020.

Last reviewed 2020-08-28 · How we verify

NCT04527640

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Synbiotics Supplementation on the Uremic Toxin Indoxyl Sulfate Level and Constipation in End-stage Renal Disease Patients Undergoing Hemodialysis

Status unknown NA Last updated 28 August 2020

What this trial tests

NA trial testing Synbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg in Constipation in 60 participants. Status unknown.

Timeline

15 September 2020

Primary endpoint
31 January 2021

28 February 2021

Quick facts

Lead sponsor	Indonesia University
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	supportive care
Enrollment	60
Start date	15 September 2020
Primary completion	31 January 2021
Estimated completion	28 February 2021

Drugs / interventions tested

Synbiotics containing Lactobacillus acidophilus & Bifidobacterium longum 5x10^9 CFU and FOS 60 mg
Placebo

Conditions studied

Constipation — all drugs for Constipation →
End Stage Renal Disease on Dialysis — all drugs for End Stage Renal Disease on Dialysis →

Sponsor

Indonesia University

Who can join

18 and older, any sex, with Constipation or End Stage Renal Disease on Dialysis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is a double-blind, placebo-controlled, randomized clinical trial conducted to evaluate the effects of synbiotics supplementation on the level of the uremic toxin indoxyl sulfate, symptoms of constipation, and constipation-related quality of life in end-stage renal disease patients undergoing hemodialysis.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Uremic Toxins in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Mechanisms and Therapeutic Targets.
Lim YJ, Sidor NA, Tonial NC, Che A, et al · · 2021 · cited 227× · PMID 33668632 · DOI 10.3390/toxins13020142
Synbiotics, prebiotics and probiotics for people with chronic kidney disease.
Cooper TE, Khalid R, Chan S, Craig JC, et al · · 2023 · cited 35× · PMID 37870148 · DOI 10.1002/14651858.cd013631.pub2
The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial.
Lydia A, Indra TA, Rizka A, Abdullah M. · · 2022 · cited 19× · PMID 35869437 · DOI 10.1186/s12882-022-02890-9

Verify or expand the search:

Other recruiting trials for Constipation

Currently open trials in the same condition.

NCT07462481 — Probiotic Improve Constipation · NA · recruiting
NCT07466914 — Constipation in Children With Cerebral Palsy · active not recruiting
NCT07215351 — Impact of the Inno Cleanse Dietary Supplement on Gut Health and Associated Variables in Healthy Men and Women · NA · recruiting
NCT07135362 — The Efficacy Evaluation of TCI604 Probiotic on Intestinal Function Improvement · NA · recruiting
NCT07091084 — A Study of Herbal Supplements in Cancer Survivors With Constipation · NA · recruiting

Other Indonesia University trials

Trials by the same sponsor.

NCT07137130 — Secretome TGF Beta 3 · NA · not yet recruiting
NCT07420335 — Preoperative Shoulder Exercises and Postoperative Inflammation, Pain, and Function After Modified Radical Mastectomy · NA · not yet recruiting
NCT07278284 — The Effectiveness of Press Needle Acupuncture on Preoperative Anxiety in Tympanoplasty and Mastoidectomy · NA · recruiting
NCT07337187 — Effect of Thread-Embedding Acupuncture at EX-B2 on Pain and Quality of Life in Chronic Low Back Pain · NA · not yet recruiting
NCT07242001 — Laser Acupuncture for Otitis Media With Effusion in Children · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT04527640 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Indonesia University
Last refreshed: 28 August 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04527640.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing