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NCT04526236
Influence of Aging on Perioperative Methadone Dosing
Phase 4 trial testing Methadone Injectable Product in Pain, Postoperative in 60 participants. Completed in 13 July 2022.
13 July 2022
Quick facts
| Lead sponsor | Pontificia Universidad Catolica de Chile |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 3 September 2019 |
| Primary completion | 13 July 2022 |
| Estimated completion | 13 July 2022 |
| Sites | 1 location across Chile |
Drugs / interventions tested
- Methadone Injectable Product — full drug profile →
Conditions studied
- Pain, Postoperative — all drugs for Pain, Postoperative →
- Opioid Use — all drugs for Opioid Use →
- Methadone Overdose of Undetermined Intent — all drugs for Methadone Overdose of Undetermined Intent →
Sponsor
Pontificia Universidad Catolica de Chile — full company profile →
Who can join
Adults 18 to 105, any sex, with Pain, Postoperative or Opioid Use. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Increasingly, elderly patients undergo anesthesia and surgery. Methadone is a great opioid for perioperative pain management, however, to date there are no pharmacokinetic or pharmacodynamic studies that asses a methadone dose adjustment in the elderly patient. The present study is aimed to characterize the pharmacokinetic and pharmacodynamic age-related changes of methadone in the adult population and further to design reference dosing protocols for intraoperative methadone use according to patient age.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT04526236
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Pontificia Universidad Catolica de Chile trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT04526236 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Pontificia Universidad Catolica de Chile
- Last refreshed: 21 December 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT04526236.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing